Anti-TRPV5 Antibody (CAB6473)
- SKU:
- CAB6473
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-TRPV5 Antibody |
| 抗体コード: | CAB6473 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-325 of human TRPV5 (NP_062815.3). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:10 - 1:100 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | 293T, HepG2, HT-29, Mouse kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-325 of human TRPV5 (NP_062815.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MGGF LPKA EGPG SQLQ KLLP SFLV REQD WDQH LDKL HMLQ QKRI LESP LLRA SKEN DLSV LRQL LLDC TCDV RQRG ALGE TALH IAAL YDNL EAAL VLME AAPE LVFE PTTC EAFA GQTA LHIA VVNQ NVNL VRAL LTRR ASVS ARAT GTAF RHSP RNLI YFGE HPLS FAAC VNSE EIVR LLIE HGAD IRAQ DSLG NTVL HILI LQPN KTFA CQMY NLLL SYDG HGDH LQPL DLVP NHQG LTPF KLAG VEGN TVMF QHLM QKRR HIQW TYGP LTSI LYDL TEID SWGE ELSF LELV VSSD KREA RQIL EQTP VKEL VSFK WNKY G |
| 遺伝子ID: | 56302 |
| Uniprot: | Q9NQA5 |
| セルラーロケーション: | Apical cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 43kDa/82kDa |
| 観察された分子量: | 83kDa |
| 同義語: | TRPV5, CAT2, ECAC1, OTRPC3 |
| バックグラウンド: | This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level. |
| UniProt Protein Function: | TRPV5: Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)- dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV5 sub-subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Motility/polarity/chemotaxis; Channel, cation Chromosomal Location of Human Ortholog: 7q35 Cellular Component: integral to plasma membrane; apical plasma membrane; plasma membrane Molecular Function:calmodulin binding; protein binding; calcium channel activity Biological Process: calcium ion transport; transmembrane transport; protein tetramerization |
| NCBI Summary: | This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NQA5 |
| NCBI GenInfo Identifier: | 62901471 |
| NCBI Gene ID: | 56302 |
| NCBI Accession: | Q9NQA5.2 |
| UniProt Secondary Accession: | Q9NQA5,Q8N4C1, Q8NDW5, Q8NDX7, Q8NDX8, Q96PM6, A4D2H7 E9PBZ6, |
| UniProt Related Accession: | Q9NQA5 |
| Molecular Weight: | 729 |
| NCBI Full Name: | Transient receptor potential cation channel subfamily V member 5 |
| NCBI Synonym Full Names: | transient receptor potential cation channel, subfamily V, member 5 |
| NCBI Official Symbol: | TRPV5 |
| NCBI Official Synonym Symbols: | CAT2; ECAC1; OTRPC3 |
| NCBI Protein Information: | transient receptor potential cation channel subfamily V member 5; calcium transporter 2; osm-9-like TRP channel 3; calcium transport protein 2; epithelial calcium channel 1 |
| UniProt Protein Name: | Transient receptor potential cation channel subfamily V member 5 |
| UniProt Synonym Protein Names: | Calcium transport protein 2; CaT2; Epithelial calcium channel 1; ECaC; ECaC1; Osm-9-like TRP channel 3; OTRPC3 |
| Protein Family: | Transient receptor potential cation channel subfamily |
| UniProt Gene Name: | TRPV5 |
| UniProt Entry Name: | TRPV5_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TRPV5 antibody (CAB6473) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of U2OS cells using TRPV5 antibody (CAB6473). |
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