Anti-TRPM7 Antibody (CAB10075)
- SKU:
- CAB10075
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-TRPM7 Antibody |
| 抗体コード: | CAB10075 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 756-855 of human TRPM7 (NP_060142.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse |
| ポジティブサンプル: | Mouse skeletal muscle |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 756-855 of human TRPM7 (NP_060142.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | NSWY KVIL SILV PPAI LLLE YKTK AEMS HIPQ SQDA HQMT MDDS ENNF QNIT EEIP MEVF KEVR ILDS NEGK NEME IQMK SKKL PITR KFYA FYHA PIVK |
| 遺伝子ID: | 54822 |
| Uniprot: | Q96QT4 |
| セルラーロケーション: | Membrane, Multi-pass membrane protein |
| 計算された分子量: | 212kDa |
| 観察された分子量: | 230kDa |
| 同義語: | TRPM7, ALSPDC, CHAK, CHAK1, LTRPC7, LTrpC-7, TRP-PLIK |
| バックグラウンド: | The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. Alternative splicing of this gene results in multiple transcript variants. |
| UniProt Protein Function: | ChaK1: is an unusual and ubiquitous bifunctional protein containing a transient receptor potential (TRP) ion channel fused to a protein kinase of the Atypical alpha group. Required for early embryonic development and for maintaining cardiac automaticity. The channel conducts Zn(2+), Mg(2+), and Ca(2+) as well as monovalent cations. The kinase can be cleaved from the channel domain. The cleaved kinase translocates to the nucleus where it binds chromatin-remodeling complexes including Polycomb, and phosphorylates specific histone residues. The kinase activity is essential for the channel function, and channel function is critical to maintain physiological intracellular magnesium levels. Plays a key role in oxidative stress-induced cell death. TRP voltage-independent calcium-permeable cation channels are divided into six subfamilies, two of which (TRPC and TRPM) have members that are widely expressed and activated by oxidative stress. Is activated by reactive oxygen/nitrogen species, resulting in cation conductance and anoxic neuronal cell death. This phenotype is rescued by suppression of ChaK1 expression. Related to ChaK2, another Atypical alpha kinase fused to a TRP ion channel protein. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Channel, cation; EC 2.7.11.1; Kinase, protein; Protein kinase, atypical; Membrane protein, integral; ATYPICAL group; Alpha family; ChaK subfamily Chromosomal Location of Human Ortholog: 15q21 Cellular Component: plasma membrane Molecular Function:calcium channel activity Disease: Amyotrophic Lateral Sclerosis-parkinsonism/dementia Complex 1 |
| NCBI Summary: | The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
| UniProt Code: | Q96QT4 |
| NCBI GenInfo Identifier: | 56404941 |
| NCBI Gene ID: | 54822 |
| NCBI Accession: | Q96QT4.1 |
| UniProt Secondary Accession: | Q96QT4,Q6ZMF5, Q86VJ4, Q8NBW2, Q9BXB2, Q9NXQ2, |
| UniProt Related Accession: | Q96QT4 |
| Molecular Weight: | |
| NCBI Full Name: | Transient receptor potential cation channel subfamily M member 7 |
| NCBI Synonym Full Names: | transient receptor potential cation channel subfamily M member 7 |
| NCBI Official Symbol: | TRPM7 |
| NCBI Official Synonym Symbols: | CHAK; CHAK1; ALSPDC; LTRPC7; LTrpC-7; TRP-PLIK |
| NCBI Protein Information: | transient receptor potential cation channel subfamily M member 7 |
| UniProt Protein Name: | Transient receptor potential cation channel subfamily M member 7 |
| UniProt Synonym Protein Names: | Channel-kinase 1; Long transient receptor potential channel 7; LTrpC-7; LTrpC7 |
| Protein Family: | Transient receptor potential cation channel subfamily |
| UniProt Gene Name: | TRPM7 |
| UniProt Entry Name: | TRPM7_HUMAN |
 | Western blot analysis of extracts of mouse skeletal muscle, using TRPM7 antibody (CAB10075) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
View AllClose