Anti-TRPA1 Antibody (CAB8568)
- SKU:
- CAB8568
- Product type:
- Antibody
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-TRPA1 Antibody |
| 抗体コード: | CAB8568 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 850-950 of human TRPA1 (NP_015628.2). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Mouse liver |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 850-950 of human TRPA1 (NP_015628.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LQRF ENCG IFIV MLEV ILKT LLRS TVVF IFLL LAFG LSFY ILLN LQDP FSSP LLSI IQTF SMML GDIN YRES FLEP YLRN ELAH PVLS FAQL VSFT IFVP I |
| 遺伝子ID: | 8989 |
| Uniprot: | O75762 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 127kDa |
| 観察された分子量: | 128kDa |
| 同義語: | TRPA1, ANKTM1, FEPS |
| バックグラウンド: | The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. |
| UniProt Protein Function: | TRPA1: Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)- tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system. Belongs to the transient receptor (TC 1.A.4) family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 8q21.11 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:calcium channel activity; calcium-release channel activity; channel activity Biological Process: ion transport; protein homotetramerization; response to organic substance; sensory perception of pain Disease: Episodic Pain Syndrome, Familial, 1 |
| NCBI Summary: | The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O75762 |
| NCBI GenInfo Identifier: | 313104269 |
| NCBI Gene ID: | 8989 |
| NCBI Accession: | O75762.3 |
| UniProt Secondary Accession: | O75762,A6NIN6, |
| UniProt Related Accession: | O75762 |
| Molecular Weight: | 128kDa |
| NCBI Full Name: | Transient receptor potential cation channel subfamily A member 1 |
| NCBI Synonym Full Names: | transient receptor potential cation channel subfamily A member 1 |
| NCBI Official Symbol: | TRPA1 |
| NCBI Official Synonym Symbols: | FEPS; ANKTM1 |
| NCBI Protein Information: | transient receptor potential cation channel subfamily A member 1 |
| UniProt Protein Name: | Transient receptor potential cation channel subfamily A member 1 |
| UniProt Synonym Protein Names: | Ankyrin-like with transmembrane domains protein 1; Transformation-sensitive protein p120 |
| Protein Family: | Transient receptor potential cation channel subfamily |
| UniProt Gene Name: | TRPA1 |
 | Western blot analysis of extracts of mouse liver, using TRPA1 antibody (CAB8568) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat brain using TRPA1 antibody (CAB8568) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using TRPA1 antibody (CAB8568) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse heart using TRPA1 antibody (CAB8568) at dilution of 1:100 (40x lens). |
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