Anti-TRIP4 Antibody (CAB15352)
- SKU:
- CAB15352
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-TRIP4 Antibody |
抗体コード: | CAB15352 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IP |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 282-581 of human TRIP4 (NP_057297.2). |
申し込み: | WB IHC IP |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IP 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | A-549, HeLa, LO2, Mouse liver, Mouse testis, Mouse brain, Rat testis, Rat brain |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 282-581 of human TRIP4 (NP_057297.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | VIDD ESDY FASD SNQW LSKL ERET LQKR EEEL RELR HASR LSKK VTID FAGR KILE EENS LAEY HSRL DETI QAIA NGTL NQPL TKLD RSSE EPLG VLVN PNMY QSPP QWVD HTGA ASQK KAFR SSGF GLEF NSFQ HQLR IQDQ EFQE GFDG GWCL SVHQ PWAS LLVR GIKR VEGR SWYT PHRG RLWI AATA KKPS PQEV SELQ ATYR LLRG KDVE FPND YPSG CLLG CVDL IDCL SQKQ FKEQ FPDI SQES DSPF VFIC KNPQ EMVV KFPI KGNP KIWK LDSK IHQG AKKG LMKQ NKAV |
遺伝子ID: | 9325 |
Uniprot: | Q15650 |
セルラーロケーション: | Cytoplasm, Nucleus, centrosome, cytoskeleton, cytosol, microtubule organizing center |
計算された分子量: | 66kDa |
観察された分子量: | 66kDa |
同義語: | TRIP4, ASC-1, ASC1, HsT17391, MDCDC, SMABF1, ZC2HC5 |
バックグラウンド: | This gene encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with transcriptional coactivators, nuclear receptors and basal transcription factors to facilitate nuclear receptors-mediated transcription. This protein is localized in the nucleus and contains an E1A-type zinc finger domain, which mediates interaction with transcriptional coactivators and ligand-bound nuclear receptors, such as thyroid hormone receptor and retinoid X receptor alpha, but not glucocorticoid receptor. Mutations in this gene are associated with spinal muscular atrophy with congenital bone fractures-1 (SMABF1). |
UniProt Protein Function: | TRIP4: thyroid receptor interacting protein 4 is a transcription coactivator of nuclear receptors including thyroid hormone receptor. Functions in conjunction with CBP-p300 and SRC-1. Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B. Plays a role in androgen receptor transactivation and in testicular function |
UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 15q22.31 Cellular Component: cytoplasm; cytosol; microtubule organizing center; nucleoplasm; nucleus Molecular Function:estrogen receptor binding; histone acetyltransferase binding; ligand-dependent nuclear receptor binding; protease binding; protein binding; transcription coactivator activity; zinc ion binding Biological Process: estrogen receptor signaling pathway; positive regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter |
NCBI Summary: | This gene encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with transcriptional coactivators, nuclear receptors and basal transcription factors to facilitate nuclear receptors-mediated transcription. This protein is localized in the nucleus and contains an E1A-type zinc finger domain, which mediates interaction with transcriptional coactivators and ligand-bound nuclear receptors, such as thyroid hormone receptor and retinoid X receptor alpha, but not glucocorticoid receptor. Mutations in this gene are associated with spinal muscular atrophy with congenital bone fractures-1 (SMABF1). [provided by RefSeq, Apr 2016] |
UniProt Code: | Q15650 |
NCBI GenInfo Identifier: | 116242828 |
NCBI Gene ID: | 9325 |
NCBI Accession: | Q15650.4 |
UniProt Secondary Accession: | Q15650,Q96ED7, Q9UKH0, B2RAS0, |
UniProt Related Accession: | Q15650 |
Molecular Weight: | 66,146 Da |
NCBI Full Name: | Activating signal cointegrator 1 |
NCBI Synonym Full Names: | thyroid hormone receptor interactor 4 |
NCBI Official Symbol: | TRIP4 |
NCBI Official Synonym Symbols: | ASC1; ASC-1; SMABF1; ZC2HC5; HsT17391 |
NCBI Protein Information: | activating signal cointegrator 1 |
UniProt Protein Name: | Activating signal cointegrator 1 |
UniProt Synonym Protein Names: | Thyroid receptor-interacting protein 4 |
Protein Family: | Activating signal cointegrator |
UniProt Gene Name: | TRIP4 |
UniProt Entry Name: | TRIP4_HUMAN |
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