Anti-TRIM11 Antibody (CAB13887)
- SKU:
- CAB13887
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
抗体名: | Anti-TRIM11 Antibody |
抗体コード: | CAB13887 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 267-468 of human TRIM11 (NP_660215.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | U-87MG, 293T, A-431 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 267-468 of human TRIM11 (NP_660215.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MELR TVCR VPGL VETL RRFR GDVT LDPD TANP ELIL SEDR RSVQ RGDL RQAL PDSP ERFD PGPC VLGQ ERFT SGRH YWEV EVGD RTSW ALGV CREN VNRK EKGE LSAG NGFW ILVF LGSY YNSS ERAL APLR DPPR RVGI FLDY EAGH LSFY SATD GSLL FIFP EIPF SGTL RPLF SPLS SSPT PMTI CRPK GGSG DTLA PQ |
遺伝子ID: | 81559 |
Uniprot: | Q96F44 |
セルラーロケーション: | Cytoplasm, Nucleus |
計算された分子量: | 42kDa/52kDa |
観察された分子量: | 52kDa |
同義語: | TRIM11, BIA1, RNF92 |
バックグラウンド: | The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nucleus and the cytoplasm. Its function has not been identified. |
UniProt Protein Function: | TRIM11: E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle. Belongs to the TRIM/RBCC family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Ubiquitin conjugating system; Ligase; EC 6.3.2.-; EC 6.3.2.19; Ubiquitin ligase Chromosomal Location of Human Ortholog: 1q42.13 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding Biological Process: innate immune response; negative regulation of viral transcription; negative regulation of virion penetration into host cell; positive regulation of virion penetration into host cell |
NCBI Summary: | The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nucleus and the cytoplasm. Its function has not been identified. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q96F44 |
NCBI GenInfo Identifier: | 26400672 |
NCBI Gene ID: | 81559 |
NCBI Accession: | Q96F44.2 |
UniProt Secondary Accession: | Q96F44,Q5VSU1, Q8NCA6, Q9C022, A6NKE2, B2RB82, B3KUS3 B4DX88, |
UniProt Related Accession: | Q96F44 |
Molecular Weight: | 52,646 Da |
NCBI Full Name: | E3 ubiquitin-protein ligase TRIM11 |
NCBI Synonym Full Names: | tripartite motif containing 11 |
NCBI Official Symbol: | TRIM11 |
NCBI Official Synonym Symbols: | BIA1; RNF92 |
NCBI Protein Information: | E3 ubiquitin-protein ligase TRIM11 |
UniProt Protein Name: | E3 ubiquitin-protein ligase TRIM11 |
UniProt Synonym Protein Names: | Protein BIA1; RING finger protein 92; Tripartite motif-containing protein 11 |
Protein Family: | E3 ubiquitin-protein ligase |
UniProt Gene Name: | TRIM11 |
UniProt Entry Name: | TRI11_HUMAN |
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