Anti-TREX1 Antibody (CAB3819)
- SKU:
- CAB3819
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| 抗体名: | Anti-TREX1 Antibody |
| 抗体コード: | CAB3819 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | A synthesized peptide derived from human TREX1 |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | HeLa, HT-29, Jurkat |
| 免疫原: | A synthesized peptide derived from human TREX1 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 11277 |
| Uniprot: | Q9NSU2 |
| セルラーロケーション: | |
| 計算された分子量: | 33kDa |
| 観察された分子量: | 33KDa |
| 同義語: | AGS1, CRV, DRN3, HERNS |
| バックグラウンド: | This gene encodes a nuclear protein with 3' exonuclease activity. The encoded protein may play a role in DNA repair and serve as a proofreading function for DNA polymerase. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012] |
| UniProt Protein Function: | TREX1: the major 3' DNA exonuclease in mammalian cells. Normally associates with the endoplasmic reticulum (ER). Translocates to the nucleus at S phase after DNA damage by gamma-irradiation or hydroxyurea. Trex1-deficient cells show defective G1/S transition, with single-stranded DNA molecules persisting after S phase and accumulating in the ER. Degrades ssDNA. Prevents chronic checkpoint activation and inappropriate immune activation. Mutations cause Aicardi-Goutieres syndrome, an autoimmune disorder. Trex1a(-/-) mice have autoinflammatory responses. The gene for this protein is either identical to or adjacent to that of ATRIP. Some of the mRNAs that encode TREX1 also encode ATRIP in another reading frame. Three alternatively spliced human isoforms have been reported. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; DNA repair, damage; Deoxyribonuclease; EC 3.1.11.2; DNA-binding Chromosomal Location of Human Ortholog: 3p21.31 Cellular Component: endoplasmic reticulum membrane; nucleolus; nuclear envelope; nucleus; cytosol Molecular Function:protein homodimerization activity; metal ion binding; double-stranded DNA binding; 3'-5'-exodeoxyribonuclease activity; exodeoxyribonuclease III activity; MutLalpha complex binding; adenyl deoxyribonucleotide binding; 3'-5' exonuclease activity; MutSalpha complex binding; single-stranded DNA binding Biological Process: regulation of interferon type I production; mismatch repair; positive regulation of interferon type I production; innate immune response; DNA replication; DNA repair; DNA catabolic process, exonucleolytic; DNA metabolic process; DNA recombination Disease: Chilblain Lupus 1; Vasculopathy, Retinal, With Cerebral Leukodystrophy; Aicardi-goutieres Syndrome 1; Systemic Lupus Erythematosus |
| NCBI Summary: | This gene encodes a nuclear protein with 3' exonuclease activity. The encoded protein may play a role in DNA repair and serve as a proofreading function for DNA polymerase. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012] |
| UniProt Code: | Q9NSU2 |
| NCBI GenInfo Identifier: | 47606216 |
| NCBI Gene ID: | 11277 |
| NCBI Accession: | Q9NSU2.1 |
| UniProt Secondary Accession: | Q9NSU2,Q8TEU2, Q9BPW1, Q9Y4X2, B2RCN9, |
| UniProt Related Accession: | Q9NSU2 |
| Molecular Weight: | 369 |
| NCBI Full Name: | Three-prime repair exonuclease 1 |
| NCBI Synonym Full Names: | three prime repair exonuclease 1 |
| NCBI Official Symbol: | TREX1 |
| NCBI Official Synonym Symbols: | CRV; AGS1; DRN3; HERNS |
| NCBI Protein Information: | three-prime repair exonuclease 1; DNase III; deoxyribonuclease III; 3' repair exonuclease 1; 3'-5' exonuclease TREX1 |
| UniProt Protein Name: | Three-prime repair exonuclease 1 |
| UniProt Synonym Protein Names: | 3'-5' exonuclease TREX1; DNase III |
| Protein Family: | Three-prime repair exonuclease |
| UniProt Gene Name: | TREX1 |
| UniProt Entry Name: | TREX1_HUMAN |
 | Western blot - TREX1 Rabbit mAb (CAB3819) |