Anti-TPM4 Antibody (CAB4166)
- SKU:
- CAB4166
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-TPM4 Antibody |
| 抗体コード: | CAB4166 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-248 of human TPM4 (NP_003281.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Mouse lung, Rat heart |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-248 of human TPM4 (NP_003281.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MAGL NSLE AVKR KIQA LQQQ ADEA EDRA QGLQ RELD GERE RREK AEGD VAAL NRRI QLVE EELD RAQE RLAT ALQK LEEA EKAA DESE RGMK VIEN RAMK DEEK MEIQ EMQL KEAK HIAE EADR KYEE VARK LVIL EGEL ERAE ERAE VSEL KCGD LEEE LKNV TNNL KSLE AASE KYSE KEDK YEEE IKLL SDKL KEAE TRAE FAER TVAK LEKT IDDL EEKL AQAK EENV GLHQ TLDQ TLNE LNCI |
| 遺伝子ID: | 7171 |
| Uniprot: | P67936 |
| セルラーロケーション: | Cytoplasm, cytoskeleton |
| 計算された分子量: | 28kDa/32kDa |
| 観察された分子量: | 36kDa |
| 同義語: | TPM4, HEL-S-108 |
| バックグラウンド: | This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | TPM4: a cytoskeletal protein that binds to actin filaments in muscle and nonmuscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments and endocytosis. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 19p13.1 Cellular Component: cytoskeleton; cytosol; focal adhesion; membrane; muscle thin filament tropomyosin; stress fiber Molecular Function:protein binding; structural constituent of muscle Biological Process: cell motility; muscle contraction; muscle filament sliding; osteoblast differentiation |
| NCBI Summary: | This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009] |
| UniProt Code: | P67936 |
| NCBI GenInfo Identifier: | 54039751 |
| NCBI Gene ID: | 7171 |
| NCBI Accession: | P67936.3 |
| UniProt Secondary Accession: | P67936,P07226, Q15659, Q5U0D9, Q9BU85, Q9H8Q3, Q9UCS1 Q9UCS2, Q9UCS3, Q9UCS4, |
| UniProt Related Accession: | P67936 |
| Molecular Weight: | 32,723 Da |
| NCBI Full Name: | Tropomyosin alpha-4 chain |
| NCBI Synonym Full Names: | tropomyosin 4 |
| NCBI Official Symbol: | TPM4 |
| NCBI Official Synonym Symbols: | HEL-S-108 |
| NCBI Protein Information: | tropomyosin alpha-4 chain |
| UniProt Protein Name: | Tropomyosin alpha-4 chain |
| UniProt Synonym Protein Names: | TM30p1; Tropomyosin-4 |
| Protein Family: | Tropomyosin |
| UniProt Gene Name: | TPM4 |
| UniProt Entry Name: | TPM4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TPM4 antibody (CAB4166) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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