Anti-TPH1 Antibody (CAB1569)
- SKU:
- CAB1569
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Neuroscience
Frequently bought together:
Description
| 抗体名: | Anti-TPH1 Antibody |
| 抗体コード: | CAB1569 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 345-444 of human TPH1 (NP_004170.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HL-60, SH-SY5Y, THP-1, Mouse brain, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 345-444 of human TPH1 (NP_004170.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LSGH AKVK PFDP KITC KQEC LITT FQDV YFVS ESFE DAKE KMRE FTKT IKRP FGVK YNPY TRSI QILK DTKS ITSA MNEL QHDL DVVS DALA KVSR KPSI |
| 遺伝子ID: | 7166 |
| Uniprot: | P17752 |
| セルラーロケーション: | |
| 計算された分子量: | 50kDa/53kDa |
| 観察された分子量: | 47kDa |
| 同義語: | TPH1, TPRH, TRPH |
| バックグラウンド: | This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others. |
| UniProt Protein Function: | TPH1: an enzyme that is rate-limiting in the biosynthesis of serotonin. It catalyzes the biopterin dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin. Its expression is limited to a few specialized tissues: raphe neurons, pinealocytes, mast cells, mononuclear leukocytes, beta-cells of the islets of Langerhans, and intestinal and pancreatic enterochromaffin cells. Two alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Amino Acid Metabolism - tryptophan; EC 1.14.16.4; Oxidoreductase Chromosomal Location of Human Ortholog: 11p15.3-p14 Cellular Component: cytosol Biological Process: indolalkylamine biosynthetic process |
| NCBI Summary: | This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009] |
| UniProt Code: | P17752 |
| NCBI GenInfo Identifier: | 116242823 |
| NCBI Gene ID: | 7166 |
| NCBI Accession: | P17752.4 |
| UniProt Secondary Accession: | P17752,O95188, O95189, Q16736, Q3KPG8, D3DQX6, |
| UniProt Related Accession: | P17752 |
| Molecular Weight: | 53,394 Da |
| NCBI Full Name: | Tryptophan 5-hydroxylase 1 |
| NCBI Synonym Full Names: | tryptophan hydroxylase 1 |
| NCBI Official Symbol: | TPH1 |
| NCBI Official Synonym Symbols: | TPRH; TRPH |
| NCBI Protein Information: | tryptophan 5-hydroxylase 1 |
| UniProt Protein Name: | Tryptophan 5-hydroxylase 1 |
| UniProt Synonym Protein Names: | Tryptophan 5-monooxygenase 1 |
| Protein Family: | Tryptophan 5-hydroxylase |
| UniProt Gene Name: | TPH1 |
| UniProt Entry Name: | TPH1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TPH1 antibody (CAB1569) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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