Anti-TPCN2 Antibody (CAB17271)
- SKU:
- CAB17271
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-TPCN2 Antibody |
| 抗体コード: | CAB17271 |
| 抗体サイズ: | 20uL, 50 uL |
| 申し込み: | WB |
| 反応性: | Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 11-85 of human TPCN2 (NP_620714.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 11-85 of human TPCN2 (NP_620714.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LLGG ARGG GGDW PAGL TTYR SIQV GPGA AARW DLCI DQAV VFIE DAIQ YRSI NHRV DASS MWLY RRYY SNVC QRT |
| 遺伝子ID: | 219931 |
| Uniprot: | Q8NHX9 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | Refer to figures |
| 同義語: | TPCN2, SHEP10, TPC2 |
| バックグラウンド: | This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation. |
| UniProt Protein Function: | TPCN2: Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily. |
| UniProt Protein Details: | Protein type:Transporter; Membrane protein, multi-pass; Membrane protein, integral; Transporter, ion channel Chromosomal Location of Human Ortholog: 11q13.3 Cellular Component: lysosomal membrane; integral to membrane; plasma membrane; endosome membrane Molecular Function:voltage-gated calcium channel activity; identical protein binding; protein binding; protein kinase binding Biological Process: cellular calcium ion homeostasis; smooth muscle contraction; calcium ion transport; release of sequestered calcium ion into cytosol; transmembrane transport Disease: Skin/hair/eye Pigmentation, Variation In, 10 |
| NCBI Summary: | This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation.[provided by RefSeq, Dec 2009] |
| UniProt Code: | Q8NHX9 |
| NCBI GenInfo Identifier: | 157502181 |
| NCBI Gene ID: | 219931 |
| NCBI Accession: | NP_620714.2 |
| UniProt Secondary Accession: | Q8NHX9,Q9NT82, |
| UniProt Related Accession: | Q8NHX9 |
| Molecular Weight: | 85,243 Da |
| NCBI Full Name: | two pore calcium channel protein 2 |
| NCBI Synonym Full Names: | two pore segment channel 2 |
| NCBI Official Symbol: | TPCN2 |
| NCBI Official Synonym Symbols: | TPC2; SHEP10 |
| NCBI Protein Information: | two pore calcium channel protein 2; two-pore calcium channel protein 2; voltage-dependent calcium channel protein TPC2 |
| UniProt Protein Name: | Two pore calcium channel protein 2 |
| UniProt Synonym Protein Names: | Voltage-dependent calcium channel protein TPC2 |
| UniProt Gene Name: | TPCN2 |
| UniProt Entry Name: | TPC2_HUMAN |