Anti-TPCN1 Antibody (CAB15847)
- SKU:
- CAB15847
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-TPCN1 Antibody |
| 抗体コード: | CAB15847 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 692-816 of human TPCN1 (NP_060371.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Rat lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 692-816 of human TPCN1 (NP_060371.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | FRMN YSRK NQDS EVDG GITL EKEI SKEE LVAV LELY REAR GASS DVTR LLET LSQM ERYQ QHSM VFLG RRSR TKSD LSLK MYQE EIQE WYEE HARE QEQQ RQLS SSAA PAAQ QPPG SRQR SQTV T |
| 遺伝子ID: | 53373 |
| Uniprot: | Q9ULQ1 |
| セルラーロケーション: | Endosome membrane, Lysosome membrane, Multi-pass membrane protein |
| 計算された分子量: | 29kDa/94kDa/101kDa |
| 観察された分子量: | 94kDa |
| 同義語: | TPCN1, TPC1 |
| バックグラウンド: | Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000 [PubMed 10753632]). |
| UniProt Protein Function: | TPCN1: one of the major voltage-gated Ca(2+) channel (VDCC) across the plasma membrane. Highest expression found in the heart and kidney, and lowest expression found in the spleen. Each of the two internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position. Two alternatively spliced human isoforms have been described. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Transporter, ion channel; Transporter; Membrane protein, multi-pass; Channel, calcium Chromosomal Location of Human Ortholog: 12q24.13 Cellular Component: endosome; endosome membrane; integral to membrane; lysosomal membrane; lysosome; plasma membrane Molecular Function:identical protein binding; protein binding; voltage-gated calcium channel activity Biological Process: positive regulation of autophagy; release of sequestered calcium ion into cytosol |
| NCBI Summary: | Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000 [PubMed 10753632]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9ULQ1 |
| NCBI GenInfo Identifier: | 29725622 |
| NCBI Gene ID: | 53373 |
| NCBI Accession: | NP_060371.2 |
| UniProt Secondary Accession: | Q9ULQ1,Q86XS9, Q8NC20, A7E258, |
| UniProt Related Accession: | Q9ULQ1 |
| Molecular Weight: | 101,796 Da |
| NCBI Full Name: | two pore calcium channel protein 1 isoform 2 |
| NCBI Synonym Full Names: | two pore segment channel 1 |
| NCBI Official Symbol: | TPCN1 |
| NCBI Official Synonym Symbols: | TPC1 |
| NCBI Protein Information: | two pore calcium channel protein 1 |
| UniProt Protein Name: | Two pore calcium channel protein 1 |
| UniProt Synonym Protein Names: | Voltage-dependent calcium channel protein TPC1 |
| UniProt Gene Name: | TPCN1 |
| UniProt Entry Name: | TPC1_HUMAN |
 | Western blot analysis of extracts of rat lung, using TPCN1 antibody (CAB15847) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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