Anti-TOP3A Antibody (CAB16988)
- SKU:
- CAB16988
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
抗体名: | Anti-TOP3A Antibody |
抗体コード: | CAB16988 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Rat |
宿主種: | Rabbit |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TOP3A (XP_011522303.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Rat |
ポジティブサンプル: |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TOP3A (XP_011522303.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MILA RNYL DVYP YDHW SDKI LPVY EQGS HFQP STVE MVDG ETSP PKLL TEAD LIAL MEKH GIGT DATH AEHI ETIK ARMY VGLT PDKR FLPG HLGM GLVE |
遺伝子ID: | 7156 |
Uniprot: | Q13472 |
セルラーロケーション: | |
計算された分子量: | 101kDa/109kDa/112kDa |
観察された分子量: | Refer to figures |
同義語: | TOP3A, TOP3, ZGRF7 |
バックグラウンド: | This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. |
UniProt Protein Function: | Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Has DNA decatenation activity. |
NCBI Summary: | This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016] |
UniProt Code: | Q13472 |
NCBI GenInfo Identifier: | 1002819406 |
NCBI Gene ID: | 7156 |
NCBI Accession: | NP_001307688.1 |
UniProt Secondary Accession: | Q13472,Q13473, A8KA61, B4DK80, D3DXC7, |
UniProt Related Accession: | Q13472 |
Molecular Weight: | 101,208 Da |
NCBI Full Name: | DNA topoisomerase 3-alpha isoform 2 |
NCBI Synonym Full Names: | DNA topoisomerase III alpha |
NCBI Official Symbol: | TOP3A |
NCBI Official Synonym Symbols: | TOP3; ZGRF7 |
NCBI Protein Information: | DNA topoisomerase 3-alpha |
UniProt Protein Name: | DNA topoisomerase 3-alpha |
UniProt Synonym Protein Names: | DNA topoisomerase III alpha |
UniProt Gene Name: | TOP3A |