Anti-TOM1L1 Antibody (CAB17602)
- SKU:
- CAB17602
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-TOM1L1 Antibody |
| 抗体コード: | CAB17602 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide of Human TOM1L1. |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 293T, HT-29, SGC-7901, Mouse kidney, Rat kidney |
| 免疫原: | A synthetic peptide of Human TOM1L1. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 10040 |
| Uniprot: | O75674 |
| セルラーロケーション: | |
| 計算された分子量: | 38kDa/44kDa/52kDa |
| 観察された分子量: | 53kDa |
 | Western blot - TOM1L1 Polyclonal Antibody (CAB17602) |
| 同義語: | SRCASM, TOM1L1 |
| バックグラウンド: |
| UniProt Protein Function: | Srcasm: an adapter protein that is a src-family kinase substrate. When phosphorylated, it binds src-family kinases and targets them for lysosomal-dependent degradation. EGF triggers a transient association of phosphorylated Srcasm with EGFR via Grb2 and Shc initiating the endocytosis of the ligand-receptor complex. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. Involved in multivesicular body (MVB) formation, viral egress from the cell, and cytokinesis. Belongs to the TOM1 family. Interacts with FYN, GRB2 and PIK3R1 when phosphorylated. The PTAP sequence in the GAT domain and the PSAP sequence in the C-terminal region are responsible for its interaction with the UEV domain of Tsg101, a component of the ESCRT-1 complex. Localizes to the multivesicular body (MVB) that is involved in targeting endosomal proteins for lysosomal degradation. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 17q23.2 Cellular Component: cytoplasm; cytosol; endosome; lysosome Molecular Function:clathrin binding; protein binding; protein kinase binding; ubiquitin binding Biological Process: activation of protein kinase activity; negative regulation of mitosis; positive regulation of protein amino acid autophosphorylation; signal transduction |
| UniProt Code: | O75674 |
| NCBI GenInfo Identifier: | 215273903 |
| NCBI Gene ID: | 10040 |
| NCBI Accession: | O75674.2 |
| UniProt Secondary Accession: | O75674,Q53G06, Q8N749, B7Z9E2, |
| UniProt Related Accession: | O75674 |
| Molecular Weight: | 44,334 Da |
| NCBI Full Name: | TOM1-like protein 1 |
| NCBI Synonym Full Names: | target of myb1 like 1 membrane trafficking protein |
| NCBI Official Symbol: | TOM1L1 |
| NCBI Official Synonym Symbols: | SRCASM |
| NCBI Protein Information: | TOM1-like protein 1 |
| UniProt Protein Name: | TOM1-like protein 1 |
| UniProt Synonym Protein Names: | Src-activating and signaling molecule protein; Target of Myb-like protein 1 |
| Protein Family: | TOM1-like protein |
| UniProt Gene Name: | TOM1L1 |
| UniProt Entry Name: | TM1L1_HUMAN |