Anti-TNNT3 Antibody (CAB15323)
- SKU:
- CAB15323
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-TNNT3 Antibody |
抗体コード: | CAB15323 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 147-256 of human TNNT3 (NP_001036246.1). |
申し込み: | WB |
推奨希釈: | WB 1:200 - 1:2000 |
反応性: | Mouse, Rat |
ポジティブサンプル: | Mouse skeletal muscle, Rat skeletal muscle, Rat lung |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 147-256 of human TNNT3 (NP_001036246.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | SMGA NYSS YLAK ADQK RGKK QTAR EMKK KILA ERRK PLNI DHLG EDKL RDKA KELW ETLH QLEI DKFE FGEK LKRQ KYDI TTLR SRID QAQK HSKK AGTP AKGK VGGR WK |
遺伝子ID: | 7140 |
Uniprot: | P45378 |
セルラーロケーション: | |
計算された分子量: | 29kDa/30kDa/31kDa |
観察された分子量: | 37kDa |
同義語: | TNNT3, TNTF, troponin T3 |
バックグラウンド: | The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). |
UniProt Protein Function: | Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
NCBI Summary: | The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). [provided by RefSeq, Oct 2009] |
UniProt Code: | P45378 |
NCBI GenInfo Identifier: | 33518637 |
NCBI Gene ID: | 7140 |
NCBI Accession: | P45378.3 |
UniProt Secondary Accession: | P45378,Q12975, Q12976, Q12977, Q12978, Q17RG9, A8MQ76 A8MSW1, B3KPX3, B7WP64, B7ZL26, B7ZVV9, |
UniProt Related Accession: | P45378 |
Molecular Weight: | 29,735 Da |
NCBI Full Name: | Troponin T, fast skeletal muscle |
NCBI Synonym Full Names: | troponin T3, fast skeletal type |
NCBI Official Symbol: | TNNT3 |
NCBI Official Synonym Symbols: | TNTF |
NCBI Protein Information: | troponin T, fast skeletal muscle |
UniProt Protein Name: | Troponin T, fast skeletal muscle |
UniProt Synonym Protein Names: | Beta-TnTF; Fast skeletal muscle troponin T; fTnT |
Protein Family: | Troponin |
UniProt Gene Name: | TNNT3 |
UniProt Entry Name: | TNNT3_HUMAN |
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