Anti-TNIK Antibody (CAB17103)
- SKU:
- CAB17103
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Description
| 抗体名: | Anti-TNIK Antibody |
| 抗体コード: | CAB17103 |
| 抗体サイズ: | 20uL, 50 uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide of human TNIK. |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: |
| 免疫原: | A synthetic peptide of human TNIK. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 23043 |
| Uniprot: | Q9UKE5 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | Refer to figures |
| 同義語: | TNIK, MRT54 |
| バックグラウンド: | Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]). |
| UniProt Protein Function: | TNIK: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Interacts (via the CNH domain) with RAP2A (GTP-bound form preferentially); the interaction is direct and required for the activation of TNIK by RAP2A. Interacts with NEDD4; recruits RAP2A to NEDD4. Interacts with TRAF2 and NCK. Interacts with TCF7L2/TCF4 and CTNNB1; the interaction is direct. Interacts with TANC1. Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. 8 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protein kinase, STE; Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; MSN subfamily Chromosomal Location of Human Ortholog: 3q26.31 Cellular Component: apical plasma membrane; cytoplasm; cytoskeleton; nucleoplasm; nucleus Molecular Function:protein binding; protein kinase activity; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity Biological Process: actin cytoskeleton reorganization; activation of JNKK activity; cytoskeleton organization and biogenesis; microvillus biogenesis; positive regulation of defense response to virus by host; positive regulation of protein amino acid phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of dendrite morphogenesis |
| NCBI Summary: | Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9UKE5 |
| NCBI GenInfo Identifier: | 29840818 |
| NCBI Gene ID: | 23043 |
| NCBI Accession: | Q9UKE5.1 |
| UniProt Secondary Accession: | Q9UKE5,O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1 Q9UKE2, Q9UKE3, A7E2A3, A8K4U1, D3DNQ6, |
| UniProt Related Accession: | Q9UKE5 |
| Molecular Weight: | 144,251 Da |
| NCBI Full Name: | TRAF2 and NCK-interacting protein kinase |
| NCBI Synonym Full Names: | TRAF2 and NCK interacting kinase |
| NCBI Official Symbol: | TNIK |
| NCBI Official Synonym Symbols: | MRT54 |
| NCBI Protein Information: | TRAF2 and NCK-interacting protein kinase |
| UniProt Protein Name: | TRAF2 and NCK-interacting protein kinase |
| Protein Family: | TRAF2 and NCK-interacting protein kinase |
| UniProt Gene Name: | TNIK |
| UniProt Entry Name: | TNIK_HUMAN |