Anti-TNFSF8 Antibody (CAB8541)
- SKU:
- CAB8541
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-TNFSF8 Antibody |
| 抗体コード: | CAB8541 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 62-234 of human TNFSF8 (NP_001235.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HepG2, B cells, Mouse liver, Rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 62-234 of human TNFSF8 (NP_001235.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VQRT DSIP NSPD NVPL KGGN CSED LLCI LKRA PFKK SWAY LQVA KHLN KTKL SWNK DGIL HGVR YQDG NLVI QFPG LYFI ICQL QFLV QCPN NSVD LKLE LLIN KHIK KQAL VTVC ESGM QTKH VYQN LSQF LLDY LQVN TTIS VNVD TFQY IDTS TFPL ENVL SIFL YSNS D |
| 遺伝子ID: | 944 |
| Uniprot: | P32971 |
| セルラーロケーション: | Membrane, Single-pass type II membrane protein |
| 計算された分子量: | 26kDa |
| 観察された分子量: | 46kDa |
| 同義語: | TNFSF8, CD153, CD30L, CD30LG, TNLG3A |
| バックグラウンド: | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | TNFSF8: Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells. Belongs to the tumor necrosis factor family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cytokine; Apoptosis Chromosomal Location of Human Ortholog: 9q33 Cellular Component: extracellular space; integral to plasma membrane Molecular Function:cytokine activity; tumor necrosis factor receptor binding; receptor binding Biological Process: cell proliferation; CD8-positive, alpha-beta T cell differentiation; defense response to Gram-positive bacterium; cell-cell signaling; apoptosis; positive regulation of transcription from RNA polymerase II promoter; immune response; signal transduction |
| NCBI Summary: | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] |
| UniProt Code: | P32971 |
| NCBI GenInfo Identifier: | 416777 |
| NCBI Gene ID: | 944 |
| NCBI Accession: | P32971.1 |
| UniProt Secondary Accession: | P32971,O43404, |
| UniProt Related Accession: | P32971 |
| Molecular Weight: | 26,017 Da |
| NCBI Full Name: | Tumor necrosis factor ligand superfamily member 8 |
| NCBI Synonym Full Names: | tumor necrosis factor (ligand) superfamily, member 8 |
| NCBI Official Symbol: | TNFSF8 |
| NCBI Official Synonym Symbols: | CD153; CD30L; CD30LG |
| NCBI Protein Information: | tumor necrosis factor ligand superfamily member 8; CD30-L; CD30 ligand; CD153 antigen; CD30 antigen ligand |
| UniProt Protein Name: | Tumor necrosis factor ligand superfamily member 8 |
| UniProt Synonym Protein Names: | CD30 ligand; CD30-L; CD_antigen: CD153 |
| UniProt Gene Name: | TNFSF8 |
| UniProt Entry Name: | TNFL8_HUMAN |
View AllClose