Anti-TNFRSF13C Antibody (CAB14299)
- SKU:
- CAB14299
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-TNFRSF13C Antibody |
| 抗体コード: | CAB14299 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human TNFRSF13C (NP_443177.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | Raji, HT-29, Mouse testis, Mouse thymus |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human TNFRSF13C (NP_443177.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MRRG PRSL RGRD APAP TPCV PAEC FDLL VRHC VACG LLRT PRPK PAGA SSPA PRTA LQPQ ESVG AGAG EAAL PLPG LLFG |
| 遺伝子ID: | 115650 |
| Uniprot: | Q96RJ3 |
| セルラーロケーション: | Membrane, Single-pass type III membrane protein |
| 計算された分子量: | 18kDa |
| 観察された分子量: | 19kDa |
| 同義語: | TNFRSF13C, BAFF-R, BAFFR, BROMIX, CD268, CVID4, prolixin |
| バックグラウンド: | B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. |
| UniProt Protein Function: | BAFF-R: B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4); also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cell cycle regulation; Receptor, misc.; Cell surface Chromosomal Location of Human Ortholog: 22q13.1-q13.31 Cellular Component: integral to membrane; external side of plasma membrane Biological Process: B cell costimulation; B cell homeostasis; T cell costimulation; positive regulation of B cell proliferation; positive regulation of germinal center formation; positive regulation of T cell proliferation; positive regulation of interferon-gamma biosynthetic process Disease: Immunodeficiency, Common Variable, 2; Immunodeficiency, Common Variable, 4 |
| NCBI Summary: | B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96RJ3 |
| NCBI GenInfo Identifier: | 21264093 |
| NCBI Gene ID: | 115650 |
| NCBI Accession: | Q96RJ3.1 |
| UniProt Related Accession: | Q96RJ3 |
| Molecular Weight: | 18,935 Da |
| NCBI Full Name: | Tumor necrosis factor receptor superfamily member 13C |
| NCBI Synonym Full Names: | tumor necrosis factor receptor superfamily, member 13C |
| NCBI Official Symbol: | TNFRSF13C |
| NCBI Official Synonym Symbols: | BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin |
| NCBI Protein Information: | tumor necrosis factor receptor superfamily member 13C; BAFF receptor; BLyS receptor 3; B cell-activating factor receptor; B-cell-activating factor receptor |
| UniProt Protein Name: | Tumor necrosis factor receptor superfamily member 13C |
| UniProt Synonym Protein Names: | B-cell-activating factor receptor; BAFF receptor; BAFF-R; BLyS receptor 3; CD_antigen: CD268 |
| UniProt Gene Name: | TNFRSF13C |
| UniProt Entry Name: | TR13C_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TNFRSF13C antibody (CAB14299) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 20s. |