Anti-TMEM67 Antibody (CAB15549)
- SKU:
- CAB15549
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-TMEM67 Antibody |
| 抗体コード: | CAB15549 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 780-940 of human TMEM67 (NP_714915.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:200 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Mouse brain, Rat brain, Rat kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 780-940 of human TMEM67 (NP_714915.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LSHK CFGY YIHG RSVH GHAD TNME EMNM NLKR EAEN LCSQ RGLV PNTD GQTF EIAI SNQM RQHY DRIH ETLI RKNG PARL LSSS ASTF EQSI KAYH MMNK FLGS FIDH VHKE MDYF IKDK LLLE RILG MEFM EPME KSIF YNDE GYSF SSVL YYGN EATL L |
| 遺伝子ID: | 91147 |
| Uniprot: | Q5HYA8 |
| セルラーロケーション: | Cell membrane, Cytoplasm, Endoplasmic reticulum membrane, Multi-pass membrane protein, cilium basal body, cytoskeleton |
| 計算された分子量: | 103kDa/111kDa |
| 観察された分子量: | 115kDa |
| 同義語: | TMEM67, JBTS6, MECKELIN, MKS3, NPHP11, TNEM67, meckelin |
| バックグラウンド: | The protein encoded by this gene localizes to the primary cilium and to the plasma membrane. The gene functions in centriole migration to the apical membrane and formation of the primary cilium. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Meckel syndrome type 3 (MKS3) and Joubert syndrome type 6 (JBTS6). |
| UniProt Protein Function: | Required for ciliary structure and function. Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Involved in the regulation of cilia length and appropriate number through the control of centrosome duplication. Required for cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (SFTPC). |
| NCBI Summary: | The protein encoded by this gene localizes to the primary cilium and to the plasma membrane. The gene functions in centriole migration to the apical membrane and formation of the primary cilium. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Meckel syndrome type 3 (MKS3) and Joubert syndrome type 6 (JBTS6). [provided by RefSeq, Nov 2008] |
| UniProt Code: | Q5HYA8 |
| NCBI GenInfo Identifier: | 214830753 |
| NCBI Gene ID: | 91147 |
| NCBI Accession: | NP_001135773.1 |
| UniProt Secondary Accession: | Q5HYA8,Q3ZCX3, Q7Z5T8, Q8IZ06, B3KRU5, B3KT47, G5E9H2 |
| UniProt Related Accession: | Q5HYA8 |
| Molecular Weight: | Observed: 112 kDPredicted: 112 kDa |
| NCBI Full Name: | meckelin isoform 2 |
| NCBI Synonym Full Names: | transmembrane protein 67 |
| NCBI Official Symbol: | TMEM67 |
| NCBI Official Synonym Symbols: | MKS3; JBTS6; NPHP11; TNEM67; MECKELIN |
| NCBI Protein Information: | meckelin |
| UniProt Protein Name: | Meckelin |
| UniProt Synonym Protein Names: | Meckel syndrome type 3 protein; Transmembrane protein 67 |
| UniProt Gene Name: | TMEM67 |
 | Western blot analysis of extracts of various cell lines, using TMEM67 antibody (CAB15549) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3min. |
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