Anti-TMEM106B Antibody (CAB20165)
- SKU:
- CAB20165
- Product type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- HLD16
Frequently bought together:
Description
抗体名: | TMEM106B Rabbit pAb |
抗体コード: | CAB20165 |
サイズ: | 50uL, 100uL |
同義語: | HLD16 |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant protein of human TMEM106B. |
申し込み: | WB |
推奨される希釈: | WB 1:1000 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | U-251MG, Mouse liver, Mouse brain, Rat brain |
免疫原: | Recombinant protein of human TMEM106B. |
精製方法: | Affinity purification |
保管所: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 54664 |
Uniprot: | Q9NUM4 |
計算された分子量: | 42kDa |
観察された分子量: | 70KDa |
UniProt Protein Function: | TMEM106B: TMEM106B genotype, when containing 3 particular single-nucleotide polymorphisms, is strongly correlated with frontotemporal lobar degeneration with TAR DNA-binding protein (TDP-43) inclusions (FTLD-TDP). Frontotemporal lobar degeneration (FTLD) is the second most common cause of presenile dementia and 20% of patients with this neurodegenerative disease have autosomal dominant GRN mutations. Expression of TMEM106B associated with these polymorphisms is increased in frontal cortex of patients with FTLD-TDP compared to unaffected controls. Thus, increased TMEM106B expression in the brain may be linked to mechanisms of disease in FTLD-TDP and risk alleles confer genetic susceptibility by increasing gene expression. Belongs to the TMEM106 family.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 7p21.3Cellular Component: intracellular membrane-bound organelle; lysosomal membrane; late endosome membrane; integral to membraneMolecular Function: protein bindingBiological Process: lysosome localization; transport; dendrite morphogenesis |
UniProt Protein Details: | |
NCBI Summary: | |
UniProt Code: | Q9NUM4 |
NCBI GenInfo Identifier: | 109895058 |
NCBI Gene ID: | |
NCBI Accession: | Q9NUM4.2 |
UniProt Secondary Accession: | Q9NUM4 |
UniProt Related Accession: | Q9NUM4 |
Molecular Weight: | |
NCBI Full Name: | Transmembrane protein 106B |
NCBI Synonym Full Names: | |
NCBI Official Symbol: | |
NCBI Official Synonym Symbols: | |
NCBI Protein Information: | |
UniProt Protein Name: | Transmembrane protein 106B |
UniProt Synonym Protein Names: | |
Protein Family: | Transmembrane protein |
UniProt Gene Name: | TMEM106B |
UniProt Entry Name: | T106B_HUMAN |