Anti-TMED2 Antibody (CAB17622)
- SKU:
- CAB17622
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-TMED2 Antibody |
| 抗体コード: | CAB17622 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-170 of human TMED2 (NP_006806.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | U-87MG, HepG2, Mouse liver, Mouse kidney, Rat spleen, Rat lung, Rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-170 of human TMED2 (NP_006806.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | EITG PDNK GIYK GDRE SSGK YTFA AHMD GTYK FCFS NRMS TMTP KIVM FTID IGEA PKGQ DMET EAHQ NKLE EMIN ELAV AMTA VKHE QEYM EVRE RIHR AIND NTNS RVV |
| 遺伝子ID: | 10959 |
| Uniprot: | Q15363 |
| セルラーロケーション: | |
| 計算された分子量: | 22kDa |
| 観察された分子量: | 23kDa |
 | Western blot - TMED2 Polyclonal Antibody (CAB17622) |
| 同義語: | P24A, RNP24, p24, p24b1, p24beta1, TMED2 |
| バックグラウンド: |
| UniProt Protein Function: | TMED2: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act togther with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase- activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing. Belongs to the EMP24/GP25L family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 12q24.31 Cellular Component: COPI-coated vesicle; endoplasmic reticulum; endoplasmic reticulum membrane; ER-Golgi intermediate compartment; ER-Golgi intermediate compartment membrane; Golgi apparatus; Golgi membrane; integral to membrane; intracellular membrane-bound organelle; transport vesicle; zymogen granule membrane Molecular Function:protein binding Biological Process: COPI coating of Golgi vesicle; COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; Golgi organization and biogenesis; intracellular protein transport; retrograde vesicle-mediated transport, Golgi to ER |
| UniProt Code: | Q15363 |
| NCBI GenInfo Identifier: | 3914237 |
| NCBI Gene ID: | 10959 |
| NCBI Accession: | Q15363.1 |
| UniProt Related Accession: | Q15363 |
| Molecular Weight: | 22,761 Da |
| NCBI Full Name: | Transmembrane emp24 domain-containing protein 2 |
| NCBI Synonym Full Names: | transmembrane p24 trafficking protein 2 |
| NCBI Official Symbol: | TMED2 |
| NCBI Official Synonym Symbols: | p24; P24A; RNP24; p24b1; p24beta1 |
| NCBI Protein Information: | transmembrane emp24 domain-containing protein 2 |
| UniProt Protein Name: | Transmembrane emp24 domain-containing protein 2 |
| UniProt Synonym Protein Names: | Membrane protein p24A; p24; p24 family protein beta-1; p24beta1 |
| Protein Family: | Transmembrane emp24 domain-containing protein |
| UniProt Gene Name: | TMED2 |
| UniProt Entry Name: | TMED2_HUMAN |