Anti-TLX1 Antibody (CAB12861)
- SKU:
- CAB12861
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-TLX1 Antibody |
| 抗体コード: | CAB12861 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human TLX1 (NP_001182446.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:1000 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Jurkat, K562, Mouse spleen, Rat spleen |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human TLX1 (NP_001182446.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MEHL GPHH LHPG HAEP ISFG IDQI LNSP DQGG CMGP ASRL QDGE YGLG CLVG GAYT YGGG GSAA ATGA GGAG AYGT GGPG GPGG PAGG GGAC SMGP LTGS YNVN MALA GGPG PGGG GGSS GGAG ALSA AGVI RVPA HRPL AGAV AHPQ PLAT GLPT VPSV PAMP GVNN LTGL TFPW MESN RRYT KDRF TG |
| 遺伝子ID: | 3195 |
| Uniprot: | P31314 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 26kDa/34kDa |
| 観察された分子量: | 40kDa |
| 同義語: | TLX1, HOX11, TCL3 |
| バックグラウンド: | This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | TLX1: Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'. A chromosomal aberration involving TLX1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(10;14)(q24;q11) with TCRD. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Oncoprotein; DNA-binding Chromosomal Location of Human Ortholog: 10q24 Cellular Component: nucleus Molecular Function:protein binding; protein heterodimerization activity; sequence-specific DNA binding Biological Process: spleen development; neuron differentiation; organ formation; central nervous system development; cell fate commitment; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010] |
| UniProt Code: | P31314 |
| NCBI GenInfo Identifier: | 399982 |
| NCBI Gene ID: | 3195 |
| NCBI Accession: | P31314.1 |
| UniProt Secondary Accession: | P31314,O75699, Q5VXP2, Q9HCA0, Q9UD59, A1L4G3, |
| UniProt Related Accession: | P31314 |
| Molecular Weight: | 26,245 Da |
| NCBI Full Name: | T-cell leukemia homeobox protein 1 |
| NCBI Synonym Full Names: | T-cell leukemia homeobox 1 |
| NCBI Official Symbol: | TLX1 |
| NCBI Official Synonym Symbols: | TCL3; HOX11 |
| NCBI Protein Information: | T-cell leukemia homeobox protein 1; proto-oncogene TCL-3; homeobox protein Hox-11; T-cell leukemia/lymphoma protein 3; homeo box-11 (T-cell leukemia-3 associated breakpoint, homologous to Drosophila Notch) |
| UniProt Protein Name: | T-cell leukemia homeobox protein 1 |
| UniProt Synonym Protein Names: | Homeobox protein Hox-11; Proto-oncogene TCL-3; T-cell leukemia/lymphoma protein 3 |
| Protein Family: | T-cell leukemia homeobox protein |
| UniProt Gene Name: | TLX1 |
| UniProt Entry Name: | TLX1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TLX1 antibody (CAB12861) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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