Anti-TLR10 Antibody (CAB5852)
- SKU:
- CAB5852
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-TLR10 Antibody |
| 抗体コード: | CAB5852 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-270 of human TLR10 (NP_001182036.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | HL-60, HepG2, 293T, Mouse spleen, Mouse thymus |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-270 of human TLR10 (NP_001182036.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | DAPE LPEE RELM TNCS NMSL RKVP ADLT PATT TLDL SYNL LFQL QSSD FHSV SKLR VLIL CHNR IQQL DLKT FEFN KELR YLDL SNNR LKSV TWYL LAGL RYLD LSFN DFDT MPIC EEAG NMSH LEIL GLSG AKIQ KSDF QKIA HLHL NTVF LGFR TLPH YEEG SLPI LNTT KLHI VLPM DTNF WVLL RDGI KTSK ILEM TNID GKSQ FVSY EMQR NLSL ENAK TSVL LLNK VDLL WDDL FLIL QFVW HTS |
| 遺伝子ID: | 81793 |
| Uniprot: | Q9BXR5 |
| セルラーロケーション: | Membrane, Single-pass type I membrane protein |
| 計算された分子量: | 94kDa |
| 観察された分子量: | 95kDa |
| 同義語: | TLR10, CD290 |
| バックグラウンド: | The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. |
| UniProt Protein Function: | TLR10: Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Belongs to the Toll-like receptor family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 4p14 Cellular Component: membrane; integral to membrane; plasma membrane Molecular Function:transmembrane receptor activity Biological Process: toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; regulation of cytokine secretion; toll-like receptor signaling pathway; innate immune response; immune response; inflammatory response; toll-like receptor 10 signaling pathway; positive regulation of inflammatory response |
| NCBI Summary: | The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2010] |
| UniProt Code: | Q9BXR5 |
| NCBI GenInfo Identifier: | 116242819 |
| NCBI Gene ID: | 81793 |
| NCBI Accession: | Q9BXR5.2 |
| UniProt Secondary Accession: | Q9BXR5,Q32MI7, Q32MI8, Q5FWG4, Q6UXL3, A8K7L1, B3Y668 D1CS21, D1CS22, |
| UniProt Related Accession: | Q9BXR5 |
| Molecular Weight: | 94,564 Da |
| NCBI Full Name: | Toll-like receptor 10 |
| NCBI Synonym Full Names: | toll-like receptor 10 |
| NCBI Official Symbol: | TLR10 |
| NCBI Official Synonym Symbols: | CD290 |
| NCBI Protein Information: | toll-like receptor 10 |
| UniProt Protein Name: | Toll-like receptor 10 |
| UniProt Synonym Protein Names: | CD_antigen: CD290 |
| Protein Family: | Toll-like receptor |
| UniProt Gene Name: | TLR10 |
| UniProt Entry Name: | TLR10_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TLR10 antibody (CAB5852) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 50s. |
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