| UniProt Protein Function: | TLE4: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Homooligomer and heterooligomer with other family members. Binds PAX5, LEF1, TCF7, TCF7L1 and TCF7L2. Interacts with ZNF703; TLE4 may mediate ZNF703 transcriptional repression. In all tissues examined, mostly in brain, and muscle. Belongs to the WD repeat Groucho/TLE family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 9q21.31 Cellular Component: nucleoplasm; nucleus Molecular Function:protein binding |
| UniProt Code: | Q04727 |
| NCBI GenInfo Identifier: | 158518541 |
| NCBI Gene ID: | 7091 |
| NCBI Accession: | Q04727.3 |
| UniProt Secondary Accession: | Q04727,Q3ZCS1, Q5T1Y2, Q6PCB3, Q9BZ07, Q9BZ08, Q9BZ09 Q9NSL3, Q9ULF9, F8W6T6, |
| UniProt Related Accession: | Q04727 |
| Molecular Weight: | 81,011 Da |
| NCBI Full Name: | Transducin-like enhancer protein 4 |
| NCBI Synonym Full Names: | transducin like enhancer of split 4 |
| NCBI Official Symbol: | TLE4 |
| NCBI Official Synonym Symbols: | ESG; BCE1; ESG4; GRG4; BCE-1; Grg-4; E(spI) |
| NCBI Protein Information: | transducin-like enhancer protein 4 |
| UniProt Protein Name: | Transducin-like enhancer protein 4 |
| UniProt Synonym Protein Names: | Grg-4; Groucho-related protein 4 |
| Protein Family: | Transducin-like enhancer protein |
| UniProt Gene Name: | TLE4 |
| UniProt Entry Name: | TLE4_HUMAN |
