| UniProt Protein Function: | Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response. |
| NCBI Summary: | This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent toll-like receptor 4 pathway. [provided by RefSeq, Nov 2010] |
| UniProt Code: | Q86XR7 |
| NCBI GenInfo Identifier: | 74727858 |
| NCBI Gene ID: | 100302736 |
| NCBI Accession: | Q86XR7.1 |
| UniProt Secondary Accession: | Q86XR7,Q6JUT2, B3Y698, |
| Molecular Weight: | 46,173 Da |
| NCBI Full Name: | TIR domain-containing adapter molecule 2 |
| NCBI Synonym Full Names: | TMED7-TICAM2 readthrough |
| NCBI Official Symbol: | TMED7-TICAM2 |
| NCBI Protein Information: | TRAM adaptor with GOLD domain |
| UniProt Protein Name: | TIR domain-containing adapter molecule 2 |
| UniProt Synonym Protein Names: | Putative NF-kappa-B-activating protein 502; TRIF-related adapter molecule; Toll-like receptor adaptor protein 3; Toll/interleukin-1 receptor domain-containing protein; MyD88-4 |
| Protein Family: | TIR domain-containing adapter molecule |
| UniProt Gene Name: | TICAM2 |
| UniProt Entry Name: | TCAM2_HUMAN |
