| UniProt Protein Function: | TIAM1: modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Regulates migration, cell-matrix and cell-cell adhesion by modulating the actin cytoskeleton through the GTPase, Rac1. Binding to Rac1 and the Arp2/3 complex may drive actin polymerization at specific sites, thus inducing dynamic morphological changes. |
| UniProt Protein Details: | Protein type:GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Chromosomal Location of Human Ortholog: 21q22.11 Cellular Component: cytosol; extrinsic to internal side of plasma membrane; intercellular junction; plasma membrane Molecular Function:guanyl-nucleotide exchange factor activity; kinase binding; protein binding; Rac guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity Biological Process: cell migration; cell-matrix adhesion; ephrin receptor signaling pathway; positive regulation of apoptosis; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of protein binding; Rac protein signal transduction; regulation of small GTPase mediated signal transduction |
| UniProt Code: | Q13009 |
| NCBI GenInfo Identifier: | 152031709 |
| NCBI Gene ID: | 7074 |
| NCBI Accession: | Q13009.2 |
| UniProt Secondary Accession: | Q13009,Q17RT7, B7ZLR6, F5GZ53, |
| UniProt Related Accession: | Q13009 |
| Molecular Weight: | 178kDa |
| NCBI Full Name: | T-lymphoma invasion and metastasis-inducing protein 1 |
| NCBI Synonym Full Names: | T-cell lymphoma invasion and metastasis 1 |
| NCBI Official Symbol: | TIAM1 |
| NCBI Protein Information: | T-lymphoma invasion and metastasis-inducing protein 1 |
| UniProt Protein Name: | T-lymphoma invasion and metastasis-inducing protein 1 |
| Protein Family: | T-lymphoma invasion and metastasis-inducing protein |
| UniProt Gene Name: | TIAM1 |
