Anti-TGIF1 Antibody (CAB16984)
- SKU:
- CAB16984
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-TGIF1 Antibody |
| 抗体コード: | CAB16984 |
| 抗体サイズ: | 20uL, 50 uL |
| 申し込み: | WB IHC |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 123-272 of human TGIF1 (NP_003235.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 123-272 of human TGIF1 (NP_003235.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VESV MGIK NFMP ALEE TPFH SCTA GPNP TLGR PLSP KPSS PGSV LARP SVIC HTTV TALK DVPF SLCQ SVGV GQNT DIQQ IAAK NFTD TSLM YPED TCKS GPST NTQS GLFN TPPP TPPD LNQD FSGF QLLV DVAL KRAA EMEL QAKL TA |
| 遺伝子ID: | 7050 |
| Uniprot: | Q15583 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | Refer to figures |
| 同義語: | TGIF1, HPE4, TGIF |
| バックグラウンド: | The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. |
| UniProt Protein Function: | TGIF: Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII- RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities. Defects in TGIF1 are the cause of holoprosencephaly type 4 (HPE4). Holoprosencephaly (HPE) is the most common structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. Belongs to the TALE/TGIF homeobox family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; DNA-binding; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 18p11.3 Cellular Component: nucleoplasm Molecular Function:protein binding; transcription corepressor activity; transcription factor activity Biological Process: multicellular organismal development; negative regulation of transcription from RNA polymerase II promoter Disease: Holoprosencephaly 4 |
| NCBI Summary: | The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2013] |
| UniProt Code: | Q15583 |
| NCBI GenInfo Identifier: | 215274200 |
| NCBI Gene ID: | 7050 |
| NCBI Accession: | Q15583.3 |
| UniProt Secondary Accession: | Q15583,Q6ICR0, Q8N5X9, Q9NRS0, A6NE42, A6NLU7, F8VZB6 |
| UniProt Related Accession: | Q15583 |
| Molecular Weight: | 27,715 Da |
| NCBI Full Name: | Homeobox protein TGIF1 |
| NCBI Synonym Full Names: | TGFB induced factor homeobox 1 |
| NCBI Official Symbol: | TGIF1 |
| NCBI Official Synonym Symbols: | HPE4; TGIF |
| NCBI Protein Information: | homeobox protein TGIF1 |
| UniProt Protein Name: | Homeobox protein TGIF1 |
| UniProt Synonym Protein Names: | 5'-TG-3'-interacting factor 1 |
| Protein Family: | Homeobox protein |
| UniProt Gene Name: | TGIF1 |
| UniProt Entry Name: | TGIF1_HUMAN |