Anti-TGFB3 Antibody (CAB8460)
- SKU:
- CAB8460
- Product type:
- Antibody
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| 抗体名: | Anti-TGFB3 Antibody |
| 抗体コード: | CAB8460 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-300 of human TGFB3 (NP_003230.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | BT-474, K-937, Mouse lung, Mouse skeletal muscle, Mouse heart, Rat lung, Rat heart |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-300 of human TGFB3 (NP_003230.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | STCT TLDF GHIK KKRV EAIR GQIL SKLR LTSP PEPT VMTH VPYQ VLAL YNST RELL EEMH GERE EGCT QENT ESEY YAKE IHKF DMIQ GLAE HNEL AVCP KGIT SKVF RFNV SSVE KNRT NLFR AEFR VLRV PNPS SKRN EQRI ELFQ ILRP DEHI AKQR YIGG KNLP TRGT AEWL SFDV TDTV REWL LRRE SNLG LEIS IHCP CHTF QPNG DILE NIHE VMEI KFKG VDNE DDHG RGDL GRLK KQKD HHNP HLIL MMIP PHRL DNPG QGGQ RKKR |
| 遺伝子ID: | 7043 |
| Uniprot: | P10600 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 35kDa/47kDa |
| 観察された分子量: | 60kDa |
| 同義語: | TGFB3, ARVD, ARVD1, LDS5, RNHF, TGF-beta3 |
| バックグラウンド: | This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1. |
| UniProt Protein Function: | TGFB3: Involved in embryogenesis and cell differentiation. Homodimer; disulfide-linked. Interacts with ASPN. Belongs to the TGF-beta family. |
| UniProt Protein Details: | Protein type:Ligand, receptor tyrosine kinase; Motility/polarity/chemotaxis; Secreted; Cell development/differentiation; Secreted, signal peptide Chromosomal Location of Human Ortholog: 14q24 Cellular Component: extracellular matrix; extracellular region; extracellular space; plasma membrane Molecular Function:cytokine activity; identical protein binding; protein binding; punt binding; transforming growth factor beta binding Biological Process: alveolus development; in utero embryonic development; intercellular junction assembly and maintenance; mammary gland development; negative regulation of cell proliferation; negative regulation of DNA replication; negative regulation of neuron apoptosis; palate development; platelet degranulation; positive regulation of apoptosis; positive regulation of bone mineralization; positive regulation of collagen biosynthetic process; positive regulation of DNA replication; positive regulation of filopodium formation; positive regulation of protein secretion; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of cell proliferation; regulation of MAPKKK cascade; response to hypoxia; response to progesterone stimulus; salivary gland morphogenesis; transforming growth factor beta receptor signaling pathway; uterine wall breakdown Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 1; Rienhoff Syndrome |
| NCBI Summary: | This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Mar 2009] |
| UniProt Code: | P10600 |
| NCBI GenInfo Identifier: | 135684 |
| NCBI Gene ID: | 7043 |
| NCBI Accession: | P10600.1 |
| UniProt Secondary Accession: | P10600,Q8WV88, |
| UniProt Related Accession: | P10600 |
| Molecular Weight: | 35,708 Da |
| NCBI Full Name: | Transforming growth factor beta-3 |
| NCBI Synonym Full Names: | transforming growth factor beta 3 |
| NCBI Official Symbol: | TGFB3 |
| NCBI Official Synonym Symbols: | ARVD; LDS5; RNHF; ARVD1; TGF-beta3 |
| NCBI Protein Information: | transforming growth factor beta-3 |
| UniProt Protein Name: | Transforming growth factor beta-3 |
| Protein Family: | Transforming growth factor |
| UniProt Gene Name: | TGFB3 |
| UniProt Entry Name: | TGFB3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TGFB3 antibody (CAB8460) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded mouse lung using TGFB3 antibody (CAB8460) at dilution of 1:100 (40x lens). |