Anti-TES Antibody (CAB7094)
- SKU:
- CAB7094
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-TES Antibody |
| 抗体コード: | CAB7094 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human TES (NP_056456.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Rat |
| ポジティブサンプル: | HeLa, 22Rv1, Rat ovary |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human TES (NP_056456.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MDLE NKVK KMGL GHEQ GFGA PCLK CKEK CEGF ELHF WRKI CRNC KCGQ EEHD VLLS NEED RKVG KLFE DTKY TTLI AKLK SDGI PMYK RNVM ILTN PVAA KKNV SINT VTYE WAPP VQNQ ALAR QYMQ MLPK EKQP VAGS EGAQ YRKK QLAK QLPA HDQD PSKC HELS PREV KEME QFVK KYKS EALG VGDV KLPC EMDA QGPK QMNI PGGD RSTP AAVG AMED KSAE HKRT QYSC YCCK LSMK EGDP AIYA ERAG YDKL |
| 遺伝子ID: | 26136 |
| Uniprot: | Q9UGI8 |
| セルラーロケーション: | Cell junction, Cytoplasm, focal adhesion |
| 計算された分子量: | 46kDa/47kDa |
| 観察された分子量: | 47kDa |
| 同義語: | TES, TESS, TESS-2, testin |
| バックグラウンド: | Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. This protein is a negative regulator of cell growth and may act as a tumor suppressor. This scaffold protein may also play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Multiple protein isoforms are encoded by transcript variants of this gene. |
| UniProt Protein Function: | TES: Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth. Belongs to the prickle / espinas / testin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cytoskeletal Chromosomal Location of Human Ortholog: 7q31.2 Cellular Component: protein complex; focal adhesion; cytoplasm; plasma membrane; nucleus; cell junction Molecular Function:zinc ion binding Biological Process: negative regulation of cell proliferation |
| UniProt Code: | Q9UGI8 |
| NCBI GenInfo Identifier: | 17380320 |
| NCBI Gene ID: | |
| NCBI Accession: | Q9UGI8.1 |
| Molecular Weight: | 46kDa; 47kDa |
| NCBI Full Name: | Testin |
| UniProt Protein Name: | Testin |
| UniProt Synonym Protein Names: | TESS |
| Protein Family: | Tesmin |
| UniProt Gene Name: | TES |
| UniProt Entry Name: | TES_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TES antibody (CAB7094) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded rat ovary using TES antibody (CAB7094) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human lung cancer using TES antibody (CAB7094) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human liver cancer using TES antibody (CAB7094) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human placenta using TES antibody (CAB7094) at dilution of 1:100 (40x lens). |
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