Anti-TERF2IP Antibody (CAB15163)
- SKU:
- CAB15163
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-TERF2IP Antibody |
| 抗体コード: | CAB15163 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human TERF2IP (NP_061848.2). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human |
| ポジティブサンプル: | HeLa, NCI-H460 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human TERF2IP (NP_061848.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MAEA MDLG KDPN GPTH SSTL FVRD DGSS MSFY VRPS PAKR RLST LILH GGGT VCRV QEPG AVLL AQPG EALA EASG DFIS TQYI LDCV ERNE RLEL EAYR LGPA SAAD TGSE AKPG ALAE GAAE PEPQ RHAG RIAF TDAD DVAI LTYV KENA RSPS SVTG NALW KAME KSSL TQHS WQSL KDRY LKHL RGQE HKYL LGDA PVSP SSQK LKRK AEED PEAA DSGE PQNK RTPD LPEE EYVK EEIQ ENEE AVKK MLVE ATRE FEEV VVDE SPPD FEIH ITMC |
| 遺伝子ID: | 54386 |
| Uniprot: | Q9NYB0 |
| セルラーロケーション: | Chromosome, Cytoplasm, Nucleus, telomere |
| 計算された分子量: | 44kDa |
| 観察された分子量: | 55kDa |
| 同義語: | TERF2IP, DRIP5, RAP1 |
| バックグラウンド: | The gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on chromosomes 5 and 22. |
| UniProt Protein Function: | TERF2IP: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'- TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. Associates with the I-kappa-B-kinase (IKK) core complex, composed of CHUK, IKBKB and IKBKG. Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Interacts with TERF2; the interaction is direct. Does not interact with TERF1. Interacts with SLX4/BTBD12. Ubiquitous. Highly expressed. Belongs to the RAP1 family. |
| UniProt Protein Details: | Protein type:DNA replication Chromosomal Location of Human Ortholog: 16q23.1 Cellular Component: chromosome, telomeric region; cytoplasm; Mre11 complex; nuclear chromosome; nuclear chromosome, telomeric region; nuclear telomere cap complex; nucleoplasm; nucleus Molecular Function:protein binding; telomeric DNA binding Biological Process: activation of NF-kappaB transcription factor; negative regulation of DNA recombination at telomere; negative regulation of telomere maintenance; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of peptidyl-serine phosphorylation; protection from non-homologous end joining at telomere; regulation of transcription, DNA-dependent; telomere capping; telomere maintenance; telomere maintenance via telomerase |
| NCBI Summary: | The gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on chromosomes 5 and 22. [provided by RefSeq, Apr 2010] |
| UniProt Code: | Q9NYB0 |
| NCBI GenInfo Identifier: | 21542267 |
| NCBI Gene ID: | 54386 |
| NCBI Accession: | Q9NYB0.1 |
| UniProt Secondary Accession: | Q9NYB0,Q4W4Y2, Q8WYZ3, Q9NWR2, B4DQN4, |
| UniProt Related Accession: | Q9NYB0 |
| Molecular Weight: | 44,260 Da |
| NCBI Full Name: | Telomeric repeat-binding factor 2-interacting protein 1 |
| NCBI Synonym Full Names: | TERF2 interacting protein |
| NCBI Official Symbol: | TERF2IP |
| NCBI Official Synonym Symbols: | RAP1; DRIP5 |
| NCBI Protein Information: | telomeric repeat-binding factor 2-interacting protein 1 |
| UniProt Protein Name: | Telomeric repeat-binding factor 2-interacting protein 1 |
| UniProt Synonym Protein Names: | Dopamine receptor-interacting protein 5; Repressor/activator protein 1 homolog; RAP1 homolog; hRap1 |
| Protein Family: | Telomeric repeat-binding factor 2-interacting protein |
| UniProt Gene Name: | TERF2IP |
| UniProt Entry Name: | TE2IP_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TERF2IP Rabbit pAb (CAB15163) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of U2OS cells using TERF2IP antibody (CAB15163) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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