Anti-Tectonic-2 Antibody (CAB8260)
- SKU:
- CAB8260
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | TCTN2 Rabbit Polyclonal Antibody |
抗体コード: | CAB8260 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 420-670 of human TCTN2 (NP_079085.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Mouse |
ポジティブサンプル: | Mouse testis, Mouse brain, Mouse kidney, Mouse lung |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 420-670 of human TCTN2 (NP_079085.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | VKFL SYNS GNEE ELSG NPGY QLGK PVRA LNIN RMNN VTTL HLWQ SAGR GLCT SATF KPIL FGEN VLSG CLLE VGIN ENCT QLRE NAVE RLDS LIQA THVA MRGN SDYA DLSD GWLE IIRV DAPD PGAD PLAS SVNG MCLD IPAH LSIR ILIS DAGA VEGI TQQE ILGV ETRF SSVN WQYQ CGLT CEHK ADLL PISA SVQF IKIP AQLP HPLT RFQI NYTE YDCN RNEV CWPQ LLYP WTQY YQGE LHSQ CVA |
遺伝子ID: | 79867 |
Uniprot: | Q96GX1 |
セルラーロケーション: | Cytoplasm, Membrane, Single-pass type I membrane protein, cilium basal body, cytoskeleton |
計算された分子量: | 76kDa |
観察された分子量: | 77kDa |
同義語: | TCTN2, C12orf38, JBTS24, MKS8, TECT2 |
バックグラウンド: | This gene encodes a type I membrane protein that belongs to the tectonic family. Studies in mice suggest that this protein may be involved in hedgehog signaling, and essential for ciliogenesis. Mutations in this gene are associated with Meckel syndrome type 8. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | TCTN2: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction. Defects in TCTN2 are the cause of Meckel syndrome type 8 (MKS8). A disorder characterized by a combination of renal cysts and variably associated features including developmental anomalies of the central nervous system (typically encephalocele), hepatic ductal dysplasia and cysts, and polydactyly. Defects in TCTN2 may be a cause of Joubert syndrome, a disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable features include retinal dystrophy and renal disease. Belongs to the tectonic family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 12q24.31 Cellular Component: cytoskeleton; cytoplasm; integral to membrane Biological Process: smoothened signaling pathway; organelle organization and biogenesis; cilium biogenesis Disease: Joubert Syndrome 1; Meckel Syndrome, Type 8 |
NCBI Summary: | This gene encodes a type I membrane protein that belongs to the tectonic family. Studies in mice suggest that this protein may be involved in hedgehog signaling, and essential for ciliogenesis. Mutations in this gene are associated with Meckel syndrome type 8. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
UniProt Code: | Q96GX1 |
NCBI GenInfo Identifier: | 219803496 |
NCBI Gene ID: | 79867 |
NCBI Accession: | |
UniProt Related Accession: | Q96GX1 |
Molecular Weight: | |
NCBI Full Name: | tectonic-2 isoform 2 |
NCBI Synonym Full Names: | tectonic family member 2 |
NCBI Official Symbol: | TCTN2 |
NCBI Official Synonym Symbols: | MKS8; TECT2; JBTS24; C12orf38 |
NCBI Protein Information: | tectonic-2 |
UniProt Protein Name: | Tectonic-2 |
Protein Family: | Tectonic |
UniProt Gene Name: | TCTN2 |
UniProt Entry Name: | TECT2_HUMAN |
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