Anti-TEAD3 Antibody (CAB7454)
- SKU:
- CAB7454
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-TEAD3 Antibody |
抗体コード: | CAB7454 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 130-330 of human TEAD3 (NP_003205.2). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
反応性: | Human, Mouse |
ポジティブサンプル: | BT-474, MCF7, Mouse heart, Mouse brain |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 130-330 of human TEAD3 (NP_003205.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | SSAQ IVSA SVLQ NKFS PPSP LPQA VFST SSRF WSSP PLLG QQPG PSQD IKPF AQPA YPIQ PPLP PTLS SYEP LAPL PSAA ASVP VWQD RTIA SSRL RLLE YSAF MEVQ RDPD TYSK HLFV HIGQ TNPA FSDP PLEA VDVR QIYD KFPE KKGG LKEL YEKG PPNA FFLV KFWA DLNS TIQE GPGA FYGV SSQY SSAD SMTI S |
遺伝子ID: | 7005 |
Uniprot: | Q99594 |
セルラーロケーション: | Nucleus |
計算された分子量: | 48kDa |
観察された分子量: | 49kDa |
同義語: | TEAD3, DTEF-1, ETFR-1, TEAD-3, TEAD5, TEF-5, TEF5 |
バックグラウンド: | This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. Translation of this protein is initiated at a non-AUG (AUA) start codon. |
UniProt Protein Function: | TEAD3: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. |
UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 6p21.2 Cellular Component: nucleoplasm Molecular Function:protein binding; transcription factor activity Biological Process: asymmetric neuroblast division; female pregnancy; regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter |
NCBI Summary: | This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. Translation of this protein is initiated at a non-AUG (AUA) start codon. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q99594 |
NCBI GenInfo Identifier: | 2501157 |
NCBI Gene ID: | 7005 |
NCBI Accession: | Q99594.2 |
UniProt Secondary Accession: | Q99594,O95910, Q5BJG7, Q8N6Y4, |
UniProt Related Accession: | Q99594 |
Molecular Weight: | 48,676 Da |
NCBI Full Name: | Transcriptional enhancer factor TEF-5 |
NCBI Synonym Full Names: | TEA domain transcription factor 3 |
NCBI Official Symbol: | TEAD3 |
NCBI Official Synonym Symbols: | TEF5; TEAD5; TEF-5; DTEF-1; ETFR-1; TEAD-3 |
NCBI Protein Information: | transcriptional enhancer factor TEF-5 |
UniProt Protein Name: | Transcriptional enhancer factor TEF-5 |
UniProt Synonym Protein Names: | DTEF-1; TEA domain family member 3; TEAD-3 |
Protein Family: | Transcriptional enhancer factor |
UniProt Gene Name: | TEAD3 |
UniProt Entry Name: | TEAD3_HUMAN |
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