| バックグラウンド: | This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | TDGF1: Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. Interacts with the activin type-1 receptor ACVR1B. Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung. |
| UniProt Protein Details: | Protein type:Membrane protein, GPI anchor; Membrane protein, peripheral; Motility/polarity/chemotaxis; Cell adhesion; Cell cycle regulation Chromosomal Location of Human Ortholog: 3p21.31 Cellular Component: extrinsic to plasma membrane; Golgi apparatus; extracellular space; cell surface; perinuclear region of cytoplasm; apical plasma membrane; plasma membrane; nucleus; lipid raft Molecular Function:protein binding; growth factor activity; receptor binding Biological Process: activation of MAPK activity; somatic stem cell maintenance; heart development; regulation of signal transduction; gastrulation; Wnt receptor signaling pathway through beta-catenin; cardiac muscle cell differentiation; BMP signaling pathway; positive regulation of fibroblast proliferation; mammary gland development; determination of anterior/posterior axis, embryo; positive regulation of cell proliferation; vasculogenesis; positive regulation of cell-matrix adhesion; cell differentiation; epidermal growth factor receptor signaling pathway; in utero embryonic development; morphogenesis of a branching structure; embryonic development; peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; cell migration during sprouting angiogenesis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of apoptosis; positive regulation of cell migration |
| NCBI Summary: | This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] |
| UniProt Code: | P13385 |
| NCBI GenInfo Identifier: | 117473 |
| NCBI Gene ID: | 6997 |
| NCBI Accession: | P13385.1 |
| UniProt Secondary Accession: | P13385,Q8TCC1, |
| UniProt Related Accession: | P13385 |
| Molecular Weight: | 21,169 Da |
| NCBI Full Name: | Teratocarcinoma-derived growth factor 1 |
| NCBI Synonym Full Names: | teratocarcinoma-derived growth factor 1 |
| NCBI Official Symbol: | TDGF1 |
| NCBI Official Synonym Symbols: | CR; CRGF; CRIPTO |
| NCBI Protein Information: | teratocarcinoma-derived growth factor 1 |
| UniProt Protein Name: | Teratocarcinoma-derived growth factor 1 |
| UniProt Synonym Protein Names: | Cripto-1 growth factor; CRGF; Epidermal growth factor-like cripto protein CR1 |
| Protein Family: | Teratocarcinoma-derived growth factor |
| UniProt Gene Name: | TDGF1 |
| UniProt Entry Name: | TDGF1_HUMAN |
