Anti-TCN2 Antibody (CAB5755)
- SKU:
- CAB5755
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-TCN2 Antibody |
| 抗体コード: | CAB5755 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-250 of human TCN2 (NP_001171655.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | SW480, MCF7, A-549, U-251MG, Mouse kidney, Mouse lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-250 of human TCN2 (NP_001171655.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | EMCE IPEM DSHL VEKL GQHL LPWM DRLS LEHL NPSI YVGL RLSS LQAG TKED LYLH SLKL GYQQ CLLG SAFS EDDG DCQG KPSM GQLA LYLL ALRA NWHD HKGH PHTS YYQY GLGI LALC LHQK RVHD SVVD KLLY AVEP FHQG HHSV DTAA MAGL AFTC LKRS NFNP GRRQ RITM AIRT VREE ILKA QTPE GHFG NVYS TPLA LQFL MTSP MRGA ELGT ACLK ARVA LLAS |
| 遺伝子ID: | 6948 |
| Uniprot: | P20062 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 44kDa/47kDa |
| 観察された分子量: | 54kDa |
| 同義語: | TCN2, D22S676, D22S750, II, TC, TC II, TC-2, TC2, TCII |
| バックグラウンド: | This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | TCN2: Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells. Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency). This results in various forms of anemia. Belongs to the eukaryotic cobalamin transport proteins family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 22q12.2 Cellular Component: lysosomal lumen; extracellular space; extracellular region; endosome Molecular Function:metal ion binding; cobalamin binding Biological Process: vitamin metabolic process; cobalamin metabolic process; cobalamin transport; cobalt ion transport; water-soluble vitamin metabolic process Disease: Transcobalamin Ii Deficiency |
| NCBI Summary: | This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010] |
| UniProt Code: | P20062 |
| NCBI GenInfo Identifier: | 224471876 |
| NCBI Gene ID: | 6948 |
| NCBI Accession: | P20062.3 |
| UniProt Secondary Accession: | P20062,Q96FD4, Q9BVI8, Q9UCI5, Q9UCI6, Q9UDM0, |
| UniProt Related Accession: | P20062,AAB25526 |
| Molecular Weight: | Calculated MW: 44kDa/47kDaObserved MW: 54kDa |
| NCBI Full Name: | Transcobalamin-2 |
| NCBI Synonym Full Names: | transcobalamin II |
| NCBI Official Symbol: | TCN2 |
| NCBI Official Synonym Symbols: | II; TC; TC2; TC-2; TCII; TC II; D22S676; D22S750 |
| NCBI Protein Information: | transcobalamin-2; macrocytic anemia; vitamin B12-binding protein 2; transcobalamin II; macrocytic anemia |
| UniProt Protein Name: | Transcobalamin-2 |
| UniProt Synonym Protein Names: | Transcobalamin II; TC II; TCII |
| Protein Family: | Transcobalamin |
| UniProt Gene Name: | TCN2 |
| UniProt Entry Name: | TCO2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TCN2 antibody (CAB5755) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunofluorescence analysis of U2OS cells using TCN2 antibody (CAB5755). Blue: DAPI for nuclear staining. |
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