Anti-TCHH Antibody (CAB15731)
- SKU:
- CAB15731
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-TCHH Antibody |
| 抗体コード: | CAB15731 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-300 of human TCHH (NP_009044.2). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | U-87MG, Jurakt, HeLa, NIH/3T3, Mouse brain, Mouse kidnay, Mouse lung, Mouse pancreas |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-300 of human TCHH (NP_009044.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | RARC DGKE SLLQ DRRQ EEDQ RRFE PRDR QLEE EPGQ RRRQ KRQE QERE LAEG EEQS EKQE RLEQ RDRQ RRDE ELWR QRQE WQER EERR AEEE QLQS CKGH ETEE FPDE EQLR RREL LELR RKGR EEKQ QQRR ERQD RVFQ EEEE KEWR KRET VLRK EEEK LQEE EPQR QREL QEEE EQLR KLER QELR RERQ EEEQ QQQR L |
| 遺伝子ID: | 7062 |
| Uniprot: | Q07283 |
| セルラーロケーション: | |
| 計算された分子量: | 253kDa |
| 観察された分子量: | 280kDa |
| 同義語: | TCHH, THH, THL, TRHY, UHS3 |
| バックグラウンド: | The protein encoded by this gene forms crosslinked complexes with itself and keratin intermediate filaments to provide mechanical strength to the hair follicle inner root sheath. The encoded protein also is important for structural integrity of the filiform papillae of the tongue. Defects in this gene are a cause of uncombable hair syndrome. |
| UniProt Protein Function: | Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation. |
| NCBI Summary: | Trichohyalin confers mechanical strength to the hair follicle inner root sheath and to other toughened epithelial tissues, such as the hard palate and filiform ridges of the tongue, by forming multiple complex crosslinks with itself and with other structural proteins (Steinert et al., 2003 [PubMed 12853460]).[supplied by OMIM, Dec 2009] |
| UniProt Code: | Q07283 |
| NCBI GenInfo Identifier: | 148746195 |
| NCBI Gene ID: | 7062 |
| NCBI Accession: | NP_009044.2 |
| UniProt Secondary Accession: | Q07283,Q5VUI3, |
| UniProt Related Accession: | Q07283 |
| Molecular Weight: | 253,925 Da |
| NCBI Full Name: | trichohyalin |
| NCBI Synonym Full Names: | trichohyalin |
| NCBI Official Symbol: | TCHH |
| NCBI Official Synonym Symbols: | THH; THL; TRHY; UHS3 |
| NCBI Protein Information: | trichohyalin |
| UniProt Protein Name: | Trichohyalin |
| Protein Family: | Trichohyalin |
| UniProt Gene Name: | TCHH |
 | Western blot analysis of extracts of various cell lines, using TCHH antibody (CAB15731) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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