Anti-TBL1X Antibody (CAB15102)
- SKU:
- CAB15102
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-TBL1X Antibody |
| 抗体コード: | CAB15102 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human TBL1X (NP_005638.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | BxPC-3, HeLa, mouse brain, mouse lung |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human TBL1X (NP_005638.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LISI LQKG LQYV EAEI SINE DGTV FDGR PIES LSLI DAVM PDVV QTRQ QAFR EKLA QQQA SAAA AAAA ATAA ATAA TTTS AGVS HQNP SKNR EATV NGEE N |
| 遺伝子ID: | 6907 |
| Uniprot: | O60907 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 57kDa/62kDa |
| 観察された分子量: | 60kDa |
| 同義語: | TBL1X, EBI, SMAP55, TBL1 |
| バックグラウンド: | The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene. |
| UniProt Protein Function: | TBL1X: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange. Belongs to the WD repeat EBI family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: Xp22.3 Cellular Component: nucleoplasm; transcriptional repressor complex; spindle microtubule; histone deacetylase complex; nucleus Molecular Function:protein C-terminus binding; protein domain specific binding; protein binding; histone binding; beta-catenin binding; transcription factor binding; transcription corepressor activity Biological Process: proteasomal ubiquitin-dependent protein catabolic process; Notch signaling pathway; establishment and/or maintenance of chromatin architecture; sensory perception of sound; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; histone deacetylation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin; cellular lipid metabolic process; proteolysis |
| NCBI Summary: | The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene. [provided by RefSeq, Nov 2008] |
| UniProt Code: | O60907 |
| NCBI GenInfo Identifier: | 226693612 |
| NCBI Gene ID: | 6907 |
| NCBI Accession: | O60907.3 |
| UniProt Secondary Accession: | O60907,Q86UY2, A8K044, A8K4J7, |
| UniProt Related Accession: | O60907 |
| Molecular Weight: | 57,049 Da |
| NCBI Full Name: | F-box-like/WD repeat-containing protein TBL1X |
| NCBI Synonym Full Names: | transducin (beta)-like 1X-linked |
| NCBI Official Symbol: | TBL1X |
| NCBI Official Synonym Symbols: | EBI; TBL1; SMAP55 |
| NCBI Protein Information: | F-box-like/WD repeat-containing protein TBL1X; transducin beta-like protein 1X; transducin-beta-like protein 1, X-linked |
| UniProt Protein Name: | F-box-like/WD repeat-containing protein TBL1X |
| UniProt Synonym Protein Names: | SMAP55; Transducin beta-like protein 1X; Transducin-beta-like protein 1, X-linked |
| Protein Family: | F-box-like/WD repeat-containing protein |
| UniProt Gene Name: | TBL1X |
| UniProt Entry Name: | TBL1X_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TBL1X antibody (CAB15102) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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