Anti-TAPBPL Antibody (CAB18294)
- SKU:
- CAB18294
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
抗体名: | Anti-TAPBPL Antibody |
抗体コード: | CAB18294 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant protein of human TAPBPL. |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: |
免疫原: | Recombinant protein of human TAPBPL. |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 55080 |
Uniprot: | Q9BX59 |
セルラーロケーション: | |
計算された分子量: | 50kDa |
観察された分子量: | Refer to figures |
同義語: | TAPBPR, TAPBP-R, TAPBPL |
バックグラウンド: | Tapasin, or TAPBP (MIM 601962), is a member of the variable-constant Ig superfamily that links major histocompatibility complex (MHC) class I molecules to the transporter associated with antigen processing (TAP; see MIM 170260) in the endoplasmic reticulum (ER). The TAPBP gene is located near the MHC complex on chromosome 6p21.3. TAPBPL is a member of the Ig superfamily that is localized on chromosome 12p13.3, a region somewhat paralogous to the MHC. |
UniProt Protein Function: | TAPBPL: Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2- microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). Expression seems to slow down and down-regulate MHC class I surface expression. {ECO:0000269|PubMed:23401559}. Induced by interferon gamma. {ECO:0000269|PubMed:23401559}. 7 isoforms of the human protein are produced by alternative splicing |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 12p13.31 Molecular Function:protein complex binding Biological Process: negative regulation of antigen processing and presentation of peptide antigen via MHC class I |
NCBI Summary: | Tapasin, or TAPBP (MIM 601962), is a member of the variable-constant Ig superfamily that links major histocompatibility complex (MHC) class I molecules to the transporter associated with antigen processing (TAP; see MIM 170260) in the endoplasmic reticulum (ER). The TAPBP gene is located near the MHC complex on chromosome 6p21.3. TAPBPL is a member of the Ig superfamily that is localized on chromosome 12p13.3, a region somewhat paralogous to the MHC.[supplied by OMIM, Mar 2008] |
UniProt Code: | Q9BX59 |
NCBI GenInfo Identifier: | 296452847 |
NCBI Gene ID: | 55080 |
NCBI Accession: | Q9BX59.2 |
UniProt Secondary Accession: | Q9BX59,Q9NWB8, |
UniProt Related Accession: | Q9BX59 |
Molecular Weight: | 55,092 Da |
NCBI Full Name: | Tapasin-related protein |
NCBI Synonym Full Names: | TAP binding protein like |
NCBI Official Symbol: | TAPBPL |
NCBI Official Synonym Symbols: | TAPBPR; TAPBP-R |
NCBI Protein Information: | tapasin-related protein |
UniProt Protein Name: | Tapasin-related protein |
UniProt Synonym Protein Names: | TAP-binding protein-like; TAP-binding protein-related protein; TAPBP-R; Tapasin-like |
Protein Family: | Tapasin-related protein |
UniProt Gene Name: | TAPBPL |
UniProt Entry Name: | TPSNR_HUMAN |