| UniProt Protein Function: | TAO2: a serine/threonine-protein kinase of the STE20 family. Activates the p38 MAPK signaling pathway through the specific activation of the upstream kinases MKK3 and MKK6. A potential multi-pass membrane protein. Activated in the DNA damage response and regulates the G2/M transition DNA damage checkpoint. Interacts with tubulins through the C-terminal domain. Involved in apoptotic processes such as membrane blebbing and apoptotic body formation. Prevents TAK1-mediated activation of IKK-alpha, and thus NF-kappa-B activation. May play a role in the osmotic stress-JNK1 pathway. An autism spectrum disorder susceptibility gene. Affects basal dendrite formation and axonal projections in cortical pyramidal neurons. Interacts with NRP1 (neuropilin 1), a receptor for the secreted guidance protein semaphorin 3A (Sema3A). Influences the formation of basal dendrites through the activation of JNK. Three isoforms of the human protein are produced by alternative splicing. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Isoform 2 and kinase-defective, as well as full-length isoform 1 are excluded from the nucleus. Catalytically active full-length phosphorylated isoform 1 localizes to microtubules in the cytoplasm predominantly on microtubule cables positioned around the nucleus. A C-terminally truncated form of isoform 1 is present in the nucleus. |
| UniProt Protein Details: | Protein type:Kinase, protein; Membrane protein, integral; Apoptosis; Protein kinase, STE; Membrane protein, multi-pass; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; TAO subfamily Chromosomal Location of Human Ortholog: 16p11.2 Cellular Component: cytoplasmic vesicle membrane; cytoskeleton; cytoplasmic membrane-bound vesicle; dendrite; cytoplasm; nucleolus; integral to membrane; nucleus; receptor complex Molecular Function:protein serine/threonine kinase activity; MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding; ATP binding Biological Process: focal adhesion formation; cell migration; activation of MAPKK activity; apoptosis; stress-activated MAPK cascade; positive regulation of JNK cascade; protein amino acid phosphorylation; positive regulation of stress-activated MAPK cascade; regulation of cell shape; response to stress; regulation of cell growth; G2/M transition DNA damage checkpoint; actin cytoskeleton organization and biogenesis; protein targeting to membrane; response to DNA damage stimulus |
| NCBI Summary: | This gene encodes a serine/threonine protein kinase that is involved in many different processes, including, cell signaling, microtubule organization and stability, and apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011] |
| UniProt Code: | Q9UL54 |
| NCBI GenInfo Identifier: | 116242813 |
| NCBI Gene ID: | 9344 |
| NCBI Accession: | Q9UL54.2 |
| UniProt Related Accession: | Q9UL54 |
| Molecular Weight: | 118kDa; 119kDa; 126kDa; 138kDa |
| NCBI Full Name: | Serine/threonine-protein kinase TAO2 |
| NCBI Synonym Full Names: | TAO kinase 2 |
| NCBI Official Symbol: | TAOK2 |
| NCBI Official Synonym Symbols: | PSK; PSK1; TAO1; TAO2; MAP3K17; PSK1-BETA |
| NCBI Protein Information: | serine/threonine-protein kinase TAO2 |
| UniProt Protein Name: | Serine/threonine-protein kinase TAO2 |
| UniProt Synonym Protein Names: | Kinase from chicken homolog C; hKFC-C; Prostate-derived sterile 20-like kinase 1; PSK-1; PSK1; Prostate-derived STE20-like kinase 1; Thousand and one amino acid protein kinase 2 |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | TAOK2 |
| UniProt Entry Name: | TAOK2_HUMAN |
