Anti-TAF6L Antibody (CAB14369)
- SKU:
- CAB14369
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-TAF6L Antibody |
| 抗体コード: | CAB14369 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IP |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human TAF6L (NP_006464.1). |
| 申し込み: | WB IP |
| 推奨希釈: | WB 1:500 - 1:2000 IP 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa, HT-29, Jurkat, Mouse thymus, Rat testis |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human TAF6L (NP_006464.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MSER EERR FVEI PRES VRLM AEST GLEL SDEV AALL AEDV CYRL REAT QNSS QFMK HTKR RKLT VEDF NRAL RWSS VEAV CGYG SQEA LPMR PARE GELY FPED REVN LVEL ALAT NIPK GCAE TAVR VHVS YLDG KGNL APQG SVPS AVSS LTDD LLKY YHQV TRAV LGDD PQLM KVAL QDLQ TNSK IGAL LPYF VYVV |
| 遺伝子ID: | 10629 |
| Uniprot: | Q9Y6J9 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 67kDa |
| 観察された分子量: | 70kDa |
| 同義語: | TAF6L, PAF65A |
| バックグラウンド: | Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is a component of the PCAF histone acetylase complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. |
| UniProt Protein Function: | TAF6L: Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Belongs to the TAF6 family. |
| UniProt Protein Details: | Protein type:Transcription initiation complex Chromosomal Location of Human Ortholog: 11q12.3 Cellular Component: histone deacetylase complex Molecular Function:DNA binding; histone acetyltransferase activity; protein binding; transcription coactivator activity Biological Process: chromatin remodeling; regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is a component of the PCAF histone acetylase complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y6J9 |
| NCBI GenInfo Identifier: | 46577572 |
| NCBI Gene ID: | 10629 |
| NCBI Accession: | Q9Y6J9.1 |
| UniProt Secondary Accession: | Q9Y6J9,Q96HA6, B2RAT0, |
| UniProt Related Accession: | Q9Y6J9 |
| Molecular Weight: | 67,814 Da |
| NCBI Full Name: | TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L |
| NCBI Synonym Full Names: | TATA-box binding protein associated factor 6 like |
| NCBI Official Symbol: | TAF6L |
| NCBI Official Synonym Symbols: | PAF65A |
| NCBI Protein Information: | TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L |
| UniProt Protein Name: | TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L |
| UniProt Synonym Protein Names: | PCAF-associated factor 65-alpha; PAF65-alpha |
| Protein Family: | TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor |
| UniProt Gene Name: | TAF6L |
| UniProt Entry Name: | TAF6L_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TAF6L antibody (CAB14369) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunoprecipitation analysis of 300ug extracts of HeLa cells using 3ug TAF6L antibody (CAB14369). Western blot was performed from the immunoprecipitate using TAF6L antibody (CAB14369) at a dilition of 1:1000. |
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