Anti-TAF1C Antibody (CAB6759)
- SKU:
- CAB6759
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-TAF1C Antibody |
抗体コード: | CAB6759 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 70-320 of human TAF1C (NP_001230085.1). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HeLa, HT-1080, 293T, MCF7, Mouse thymus, Mouse eye, Mouse brain |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 70-320 of human TAF1C (NP_001230085.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | PPLI DPWD PGLT ARDL LFRG GYRY RKRP RVVL DVTE QISR FLLD HGDV AFAP LGKL MLEN FKLE GAGS RTKK KTVV SVKK LLQD LGGH QPWG CPWA YLSN RQRR FSIL GGPI LGTS VASH LAEL LHEE LVLR WEQL LLDE ACTG GALA WVPG RTPQ FGQL VYPA GGAQ DRLH FQEV VLTP GDNP QFLG KPGR IQLQ GPVR QVVT CTVQ GETL LAVR SDYH CAVW KFGK QWQP TLLQ AMQV EKGA TGIS LSP |
遺伝子ID: | 9013 |
Uniprot: | Q15572 |
セルラーロケーション: | Nucleus |
計算された分子量: | 49kDa/58kDa/84kDa/92kDa/95kDa |
観察された分子量: | 110kDa |
同義語: | TAF1C, MGC:39976, SL1, TAFI110, TAFI95 |
バックグラウンド: | Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. |
UniProt Protein Function: | TAF1C: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transcription initiation complex Chromosomal Location of Human Ortholog: 16q24 Cellular Component: nucleoplasm Molecular Function:protein binding; DNA binding Biological Process: chromatin silencing at rDNA; transcription from RNA polymerase II promoter; negative regulation of gene expression, epigenetic; RNA elongation from RNA polymerase I promoter; transcription from RNA polymerase I promoter; gene expression; termination of RNA polymerase I transcription; transcription initiation from RNA polymerase I promoter; regulation of gene expression, epigenetic |
NCBI Summary: | Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2011] |
UniProt Code: | Q15572 |
NCBI GenInfo Identifier: | 313104019 |
NCBI Gene ID: | 9013 |
NCBI Accession: | Q15572.2 |
UniProt Secondary Accession: | Q15572,Q59F67, Q8N6V3, B7Z5K5, B7Z5S4, B7Z908, B7Z9L7 |
UniProt Related Accession: | Q15572 |
Molecular Weight: | 869 |
NCBI Full Name: | TATA box-binding protein-associated factor RNA polymerase I subunit C |
NCBI Synonym Full Names: | TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa |
NCBI Official Symbol: | TAF1C |
NCBI Official Synonym Symbols: | SL1; TAFI95; TAFI110; MGC:39976 |
NCBI Protein Information: | TATA box-binding protein-associated factor RNA polymerase I subunit C; SL1, 110kD subunit; TBP-associated factor 1C; transcription factor SL1; TATA box-binding protein-associated factor 1C; transcription initiation factor SL1/TIF-IB subunit C; RNA polymerase I-specific TBP-associated factor 110 kDa; TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kD |
UniProt Protein Name: | TATA box-binding protein-associated factor RNA polymerase I subunit C |
UniProt Synonym Protein Names: | RNA polymerase I-specific TBP-associated factor 110 kDa; TAFI110; TATA box-binding protein-associated factor 1C; TBP-associated factor 1C; Transcription initiation factor SL1/TIF-IB subunit C |
Protein Family: | TATA box-binding protein-associated factor |
UniProt Gene Name: | TAF1C |
UniProt Entry Name: | TAF1C_HUMAN |
View AllClose