Anti-TAF1B Antibody (CAB14202)
- SKU:
- CAB14202
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-TAF1B Antibody |
| 抗体コード: | CAB14202 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 369-588 of human TAF1B (NP_005671.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 369-588 of human TAF1B (NP_005671.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LFLL DDSF EWSL SNLA EKHN EKNK KDKP WFDF RKWY QIMK KAFD EKKQ KWEE ARAK YLWK SEKP LYYS FVDK PVAY KKRE MVVN LQKQ FSTL VEST ATAG KKSP SSFQ FNWT EEDT DRTC FHGH SLQG VLKE KGQS LLTK NSLY WLST QKFC RCYC THVT TYEE SNYS LSYQ FILN LFSF LLRI KTSL LHEE VSLV EKKL FEKK YSVK RKKS RSKK VRRH |
| 遺伝子ID: | 9014 |
| Uniprot: | Q53T94 |
| セルラーロケーション: | Nucleus, nucleolus |
| 計算された分子量: | 39kDa/60kDa/68kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | TAF1B, MGC:9349, RAF1B, RAFI63, SL1, TAFI63 |
| バックグラウンド: | Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | TAF1B: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during trancription initiation such as preinitiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3. Belongs to the RRN7/TAF1B family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nucleolus; DNA-binding; Transcription initiation complex Chromosomal Location of Human Ortholog: 2p25 Cellular Component: nucleoplasm Molecular Function:protein binding; TATA-binding protein binding Biological Process: positive regulation of gene expression, epigenetic; RNA elongation from RNA polymerase I promoter; termination of RNA polymerase I transcription; transcription initiation from RNA polymerase I promoter |
| NCBI Summary: | Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016] |
| UniProt Code: | Q53T94 |
| NCBI GenInfo Identifier: | 74726856 |
| NCBI Gene ID: | 9014 |
| NCBI Accession: | Q53T94.1 |
| UniProt Secondary Accession: | Q53T94,Q15574, Q8WVC3, B4DI42, F8WD72, |
| UniProt Related Accession: | Q53T94 |
| Molecular Weight: | 39,533 Da |
| NCBI Full Name: | TATA box-binding protein-associated factor RNA polymerase I subunit B |
| NCBI Synonym Full Names: | TATA-box binding protein associated factor, RNA polymerase I subunit B |
| NCBI Official Symbol: | TAF1B |
| NCBI Official Synonym Symbols: | SL1; RAF1B; RAFI63; TAFI63; MGC:9349 |
| NCBI Protein Information: | TATA box-binding protein-associated factor RNA polymerase I subunit B |
| UniProt Protein Name: | TATA box-binding protein-associated factor RNA polymerase I subunit B |
| UniProt Synonym Protein Names: | RNA polymerase I-specific TBP-associated factor 63 kDa; TAFI63; TATA box-binding protein-associated factor 1B; TBP-associated factor 1B; Transcription initiation factor SL1/TIF-IB subunit B |
| Protein Family: | Transcription initiation factor |
| UniProt Gene Name: | TAF1B |
| UniProt Entry Name: | TAF1B_HUMAN |
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