Anti-TAB2 Antibody (CAB9867)

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SKU:
CAB9867
Product type:
Antibody
Application:
WB
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
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Description

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抗体名:Anti-TAB2 Antibody
抗体コード:CAB9867
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 350-693 of human TAB2 (NP_001278963.1).
申し込み:WB
推奨希釈:WB 1:500 - 1:2000
反応性:Human, Mouse, Rat
ポジティブサンプル:HeLa, HepG2, MCF7, HT-1080, Mouse liver
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 350-693 of human TAB2 (NP_001278963.1).
精製方法:Affinity purification
ストレージバッファ:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:STSS SVNS QTLN RNQP TVYI AASP PNTD ELMS RSQP KVYI SANA ATGD EQVM RNQP TLFI STNS GASA ASRN MSGQ VSMG PAFI HHHP PKSR AIGN NSAT SPRV VVTQ PNTK YTFK ITVS PNKP PAVS PGVV SPTF ELTN LLNH PDHY VETE NIQH LTDP TLAH VDRI SETR KLSM GSDD AAYT QALL VHQK ARME RLQR ELEI QKKK LDKL KSEV NEME NNLT RRRL KRSN SISQ IPSL EEMQ QLRS CNRQ LQID IDCL TKEI DLFQ ARGP HFNP SAIH NFYD NIGF VGPV PPKP KDQR SIIK TPKT QDTE DDEG AQWN CTAC TFLN HPAL IRCE QCEM PRHF
遺伝子ID:23118
Uniprot:Q9NYJ8
セルラーロケーション:Cytoplasm, Membrane, Peripheral membrane protein, cytosol
計算された分子量:58kDa/76kDa
観察された分子量:80kDa
同義語:TAB2, CHTD2, MAP3K7IP2, TAB-2
バックグラウンド:The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants.
UniProt Protein Function:TAB2: Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'- linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development. Interacts with MAP3K7 and TRAF6. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Binds 'Lys-63'-linked polyubiquitin chains. Interacts with NCOR1 and HDAC3 to form a ternary complex. Interacts (via C-terminal) with NUMBL (via PTB domain). Interacts (via the C-terminus) with WDR34 (via WD domains). Interacts with RBCK1. Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Adaptor/scaffold

Chromosomal Location of Human Ortholog: 6q25.1

Cellular Component: cytosol; endosome membrane; plasma membrane

Molecular Function:protein binding

Biological Process: activation of MAPK activity; activation of NF-kappaB transcription factor; heart development; I-kappaB kinase/NF-kappaB cascade; JNK cascade; MyD88-dependent toll-like receptor signaling pathway; negative regulation of autophagy; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of protein kinase activity; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway

Disease: Congenital Heart Defects, Multiple Types, 2

NCBI Summary:The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
UniProt Code:Q9NYJ8
NCBI GenInfo Identifier:74753070
NCBI Gene ID:23118
NCBI Accession:Q9NYJ8.1
UniProt Secondary Accession:Q9NYJ8,O94838, Q6I9W8, Q76N06, Q9UFP7, B2RCC4, E1P5A0
UniProt Related Accession:Q9NYJ8
Molecular Weight:76kDa
NCBI Full Name:TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
NCBI Synonym Full Names:TGF-beta activated kinase 1/MAP3K7 binding protein 2
NCBI Official Symbol:TAB2  
NCBI Official Synonym Symbols:CHTD2; TAB-2; MAP3K7IP2  
NCBI Protein Information:TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
UniProt Protein Name:TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
UniProt Synonym Protein Names:Mitogen-activated protein kinase kinase kinase 7-interacting protein 2; TAK1-binding protein 2; TAB-2; TGF-beta-activated kinase 1-binding protein 2
Protein Family:TGF-beta-activated kinase 1 and MAP3K7-binding protein
UniProt Gene Name:TAB2  
Anti-TAB2 Polyclonal Antibody (CAB9867)Western blot analysis of extracts of various cell lines, using TAB2 antibody (CAB9867) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.
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