Anti-SYTL2 Antibody (CAB17169)
- SKU:
- CAB17169
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-SYTL2 Antibody |
| 抗体コード: | CAB17169 |
| 抗体サイズ: | 20uL, 50 uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 630-750 of human SYTL2 (NP_001156423). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 630-750 of human SYTL2 (NP_001156423). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | GNIQ FAIE YVES LKEL HVFV AQCK DLAA ADVK KQRS DPYV KAYL LPDK GKMG KKKT LVVK KTLN PVYN EILR YKIE KQIL KTQK LNLS IWHR DTFK RNSF LGEV ELDL ETWD WDNK QNKQ L |
| 遺伝子ID: | 54843 |
| Uniprot: | Q9HCH5 |
| セルラーロケーション: | |
| 計算された分子量: | 38-42kDa/84-141kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | SYTL2, CHR11SYT, EXO4, PPP1R151, SGA72M, SLP2, SLP2A |
| バックグラウンド: | The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A). This protein plays a role in RAB27A-dependent vesicle trafficking and controls melanosome distribution in the cell periphery. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
| UniProt Protein Function: | SYTL2: Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol- 4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon- containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. 12 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GAPs, Rab; Vesicle; Motility/polarity/chemotaxis; GAPs; Lipid-binding Chromosomal Location of Human Ortholog: 11q14 Cellular Component: cytoplasm; extrinsic to plasma membrane; melanosome; membrane; plasma membrane Molecular Function:calcium ion binding; calcium-dependent phospholipid binding; clathrin binding; neurexin binding; phosphatase binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylserine binding; protein binding; syntaxin binding Biological Process: calcium ion-dependent exocytosis of neurotransmitter; exocytosis; regulation of calcium ion-dependent exocytosis; vesicle docking during exocytosis; vesicle fusion; vesicle-mediated transport |
| NCBI Summary: | The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A). This protein plays a role in RAB27A-dependent vesicle trafficking and controls melanosome distribution in the cell periphery. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jun 2009] |
| UniProt Code: | Q9HCH5 |
| NCBI GenInfo Identifier: | 257051068 |
| NCBI Gene ID: | 54843 |
| NCBI Accession: | Q9HCH5.3 |
| UniProt Secondary Accession: | Q9HCH5,Q2YDA7, Q6TV07, Q6ZN59, Q6ZVC5, B3KRS3, B4DJT5 B4DKW3, B4DQ26, B7SA85, B7ZLX6, B7ZLX7, |
| UniProt Related Accession: | Q9HCH5 |
| Molecular Weight: | 84,651 Da |
| NCBI Full Name: | Synaptotagmin-like protein 2 |
| NCBI Synonym Full Names: | synaptotagmin like 2 |
| NCBI Official Symbol: | SYTL2 |
| NCBI Official Synonym Symbols: | EXO4; SLP2; SLP2A; SGA72M; CHR11SYT; PPP1R151 |
| NCBI Protein Information: | synaptotagmin-like protein 2 |
| UniProt Protein Name: | Synaptotagmin-like protein 2 |
| UniProt Synonym Protein Names: | Breast cancer-associated antigen SGA-72M; Exophilin-4 |
| Protein Family: | Synaptotagmin-like protein |
| UniProt Gene Name: | SYTL2 |
| UniProt Entry Name: | SYTL2_HUMAN |