Anti-SYT7 Antibody (CAB12757)
- SKU:
- CAB12757
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-SYT7 Antibody |
| 抗体コード: | CAB12757 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 38-170 of human SYT7 (NP_004191.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | HT-29, U-251MG, SW480 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 38-170 of human SYT7 (NP_004191.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | CHWC QRKL GKRY KNSL ETVG TPDS GRGR SEKK AIKL PAGG KAVN TAPV PGQT PHDE SDRR TEPR SSVS DLVN SLTS EMLM LSPG SEED EAHE GCSR ENLG RIQF SVGY NFQE STLT VKIM KAQE LPAK DFSG T |
| 遺伝子ID: | 9066 |
| Uniprot: | O43581 |
| セルラーロケーション: | Cytoplasmic vesicle, Single-pass membrane protein, secretory vesicle, synaptic vesicle membrane |
| 計算された分子量: | 45kDa/50kDa/52kDa/58kDa/68kDa/75kDa |
| 観察された分子量: | 46kDa |
| 同義語: | SYT7, IPCA-7, IPCA7, PCANAP7, SYT-VII, SYTVII |
| バックグラウンド: | This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. A similar protein in rodents mediates hormone secretion and lysosome exocytosis. In humans, expression of this gene has been associated with prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| UniProt Protein Function: | SYT7: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Belongs to the synaptotagmin family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 11q12.2 Cellular Component: lysosome; peroxisome; plasma membrane; synaptic vesicle Molecular Function:calcium ion binding; calcium-dependent phospholipid binding; calmodulin binding; clathrin binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; syntaxin binding Biological Process: calcium ion-dependent exocytosis of neurotransmitter; phagocytosis; plasma membrane repair; regulation of bone remodeling; regulation of calcium ion-dependent exocytosis; regulation of insulin secretion; regulation of phagocytosis; vesicle fusion |
| NCBI Summary: | This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. A similar protein in rodents mediates hormone secretion and lysosome exocytosis. In humans, expression of this gene has been associated with prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011] |
| UniProt Code: | O43581 |
| NCBI GenInfo Identifier: | 206729907 |
| NCBI Gene ID: | 9066 |
| NCBI Accession: | O43581.3 |
| UniProt Secondary Accession: | O43581,Q08AH6, F5GZC2, F5GZU9, F5H126, F5H1N2, F5H6C1 |
| UniProt Related Accession: | O43581 |
| Molecular Weight: | 46kDa |
| NCBI Full Name: | Synaptotagmin-7 |
| NCBI Synonym Full Names: | synaptotagmin 7 |
| NCBI Official Symbol: | SYT7 |
| NCBI Official Synonym Symbols: | IPCA7; IPCA-7; SYTVII; PCANAP7; SYT-VII |
| NCBI Protein Information: | synaptotagmin-7 |
| UniProt Protein Name: | Synaptotagmin-7 |
| UniProt Synonym Protein Names: | IPCA-7; Prostate cancer-associated protein 7; Synaptotagmin VII; SytVII |
| Protein Family: | Synaptotagmin |
| UniProt Gene Name: | SYT7 |
 | Western blot analysis of extracts of various cell lines, using SYT7 antibody (CAB12757) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s. |
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