Anti-Syntrophin alpha 1 Antibody (CAB20460)

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SKU:
CAB20460
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
LQT12
Synonyms:
SNT1
Synonyms:
TACIP1
Synonyms:
dJ1187J4.5
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Description

抗体名:Syntrophin alpha 1 Rabbit pAb
抗体コード:CAB20460
サイズ:50uL, 100uL
同義語:LQT12, SNT1, TACIP1, dJ1187J4.5
申し込み:WB, IF
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:Recombinant protein of human Syntrophin alpha 1.
申し込み:WB, IF
推奨される希釈:WB 1:500 - 1:2000 IF 1:50 - 1:200
反応性:Human, Mouse, Rat
ポジティブサンプル:HeLa, RD, Mouse skeletal muscle, Mouse brain, Mouse heart, Rat skeletal muscle, Rat kidney, Rat heart
免疫原:Recombinant protein of human Syntrophin alpha 1.
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:6640
Uniprot:Q13424
計算された分子量:54kDa
観察された分子量:59KDa
UniProt Protein Function:SNTA1: Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5- bisphosphate. Defects in SNTA1 are the cause of long QT syndrome type 12 (LQT12). A heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. Belongs to the syntrophin family. Protein type: Adaptor/scaffold; Membrane protein, peripheral; Lipid-binding Chromosomal Location of Human Ortholog: 20q11.2 Cellular Component: postsynaptic membrane; cytoskeleton; protein complex; cytoplasm; syntrophin complex; intracellular; cell junction; neuromuscular junction; sarcolemma; lateral plasma membrane Molecular Function: calmodulin binding; protein binding; sodium channel regulator activity; actin binding; nitric-oxide synthase binding; ATPase binding; PDZ domain binding Biological Process: muscle contraction; regulation of vasoconstriction by circulating norepinephrine; regulation of heart rate; neuromuscular junction development Disease: Long Qt Syndrome 12
UniProt Protein Details:
NCBI Summary:Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue. [provided by RefSeq, Jan 2013]
UniProt Code:Q13424
NCBI GenInfo Identifier:4507137
NCBI Gene ID:6640
NCBI Accession:NP_003089.1
UniProt Secondary Accession:Q13424
UniProt Related Accession:Q13424
Molecular Weight:Observed Molecular Weight: (Observed)53kD.Predicted Molecular Weight: (Calculated)54kDa.
NCBI Full Name:alpha-1-syntrophin
NCBI Synonym Full Names:syntrophin alpha 1
NCBI Official Symbol:SNTA1  
NCBI Official Synonym Symbols:SNT1; LQT12; TACIP1; dJ1187J4.5  
NCBI Protein Information:alpha-1-syntrophin
UniProt Protein Name:Alpha-1-syntrophin
UniProt Synonym Protein Names:59 kDa dystrophin-associated protein A1 acidic component 1; Pro-TGF-alpha cytoplasmic domain-interacting protein 1; TACIP1; Syntrophin-1
Protein Family:Alpha-1-syntrophin
UniProt Gene Name:SNTA1  
UniProt Entry Name:SNTA1_HUMAN
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