Anti-Syntaxin-11 Antibody (CAB8169)
- SKU:
- CAB8169
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | STX11 Rabbit Polyclonal Antibody |
| 抗体コード: | CAB8169 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-287 of human STX11 (NP_003755.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Mouse lung, Rat lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-287 of human STX11 (NP_003755.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MKDR LAEL LDLS KQYD QQFP DGDD EFDS PHED IVFE TDHI LESL YRDI RDIQ DENQ LLVA DVKR LGKQ NARF LTSM RRLS SIKR DTNS IAKA IKAR GEVI HCKL RAMK ELSE AAEA QHGP HSAV ARIS RAQY NALT LTFQ RAMH DYNQ AEMK QRDN CKIR IQRQ LEIM GKEV SGDQ IEDM FEQG KWDV FSEN LLAD VKGA RAAL NEIE SRHR ELLR LESR IRDV HELF LQMA VLVE KQAD TLNV IELN VQKT VDYT GQAK AQVR KAVQ YEEK NPCR TLCC FCCP CLK |
| 遺伝子ID: | 8676 |
| Uniprot: | O75558 |
| セルラーロケーション: | Golgi apparatus, Membrane, Peripheral membrane protein, trans-Golgi network membrane |
| 計算された分子量: | 33kDa |
| 観察された分子量: | 36kDa |
| 同義語: | STX11, FHL4, HLH4, HPLH4 |
| バックグラウンド: | This gene encodes a member of the syntaxin family. Syntaxins have been implicated in the targeting and fusion of intracellular transport vesicles. This family member may regulate protein transport among late endosomes and the trans-Golgi network. Mutations in this gene have been associated with familial hemophagocytic lymphohistiocytosis. |
| UniProt Protein Function: | STX11: SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. Defects in STX11 are the cause of familial hemophagocytic lymphohistiocytosis type 4 (FHL4); also known as HPLH4. Familial hemophagocytic lymphohistiocytosis (FHL) is a genetically heterogeneous, rare autosomal recessive disorder. It is characterized by immune dysregulation with hypercytokinemia and defective natural killer cell function. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, hypertriglyceridemia, hypofibrinogenemia, and neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits, and ataxia. Hemophagocytosis is a prominent feature of the disease, and a non-malignant infiltration of macrophages and activated T-lymphocytes in lymph nodes, spleen, and other organs is also found. Belongs to the syntaxin family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 6q24.2 Cellular Component: integral to membrane; plasma membrane; SNARE complex; synaptic vesicle Molecular Function:protein binding; SNARE binding Biological Process: intracellular protein transport; synaptic vesicle fusion to presynaptic membrane; vesicle docking Disease: Hemophagocytic Lymphohistiocytosis, Familial, 4 |
| NCBI Summary: | This gene encodes a member of the syntaxin family. Syntaxins have been implicated in the targeting and fusion of intracellular transport vesicles. This family member may regulate protein transport among late endosomes and the trans-Golgi network. Mutations in this gene have been associated with familial hemophagocytic lymphohistiocytosis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O75558 |
| NCBI GenInfo Identifier: | 6175047 |
| NCBI Gene ID: | 8676 |
| NCBI Accession: | O75558.1 |
| UniProt Secondary Accession: | O75558,O75378, O95148, Q5TCL6, E1P598, |
| UniProt Related Accession: | O75558 |
| Molecular Weight: | 33,196 Da |
| NCBI Full Name: | Syntaxin-11 |
| NCBI Synonym Full Names: | syntaxin 11 |
| NCBI Official Symbol: | STX11 |
| NCBI Official Synonym Symbols: | FHL4; HLH4; HPLH4 |
| NCBI Protein Information: | syntaxin-11 |
| UniProt Protein Name: | Syntaxin-11 |
| Protein Family: | Syntaxin |
| UniProt Gene Name: | STX11 |
| UniProt Entry Name: | STX11_HUMAN |
 | Western blot analysis of extracts of various cell lines, using STX11 antibody (CAB8169) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 45s. |
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