Anti-Syndecan-1/CD138 Antibody (CAB4174)
- SKU:
- CAB4174
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-Syndecan-1/CD138 Antibody |
抗体コード: | CAB4174 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A synthesized peptide derived from human Syndecan 1 |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HeLa, HepG2, Mouse lung, Mouse kidney, Rat liver |
免疫原: | A synthesized peptide derived from human Syndecan 1 |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 6382 |
Uniprot: | P18827 |
セルラーロケーション: | Membrane, Secreted, Single-pass type I membrane protein |
計算された分子量: | 35kDa |
観察された分子量: | 90-100KDa/180-230KDa |
同義語: | CD138, SDC, SYND1, syndecan |
バックグラウンド: | The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008] |
UniProt Protein Function: | syndecan-1: Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Belongs to the syndecan proteoglycan family. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Motility/polarity/chemotaxis; Extracellular matrix Chromosomal Location of Human Ortholog: 2p24.1 Cellular Component: cell surface; cytoplasm; focal adhesion; Golgi lumen; integral to plasma membrane; lysosomal lumen; plasma membrane Molecular Function:protein binding; protein C-terminus binding Biological Process: cell migration; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; glycosaminoglycan metabolic process; lipoprotein metabolic process; myoblast development; retinoid metabolic process; striated muscle cell development |
NCBI Summary: | The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008] |
UniProt Code: | P18827 |
NCBI GenInfo Identifier: | 229463011 |
NCBI Gene ID: | 6382 |
NCBI Accession: | P18827.3 |
UniProt Secondary Accession: | P18827,Q53QV0, Q546D3, Q96HB7, D6W523, |
UniProt Related Accession: | P18827,AAB21434,AAB23935 |
Molecular Weight: | 32,462 Da |
NCBI Full Name: | Syndecan-1 |
NCBI Synonym Full Names: | syndecan 1 |
NCBI Official Symbol: | SDC1 |
NCBI Official Synonym Symbols: | SDC; CD138; SYND1; syndecan |
NCBI Protein Information: | syndecan-1 |
UniProt Protein Name: | Syndecan-1 |
UniProt Synonym Protein Names: | CD_antigen: CD138 |
Protein Family: | COMPASS component |
UniProt Gene Name: | SDC1 |
UniProt Entry Name: | SDC1_HUMAN |
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