Anti-Syndecan-1/CD138 Antibody (CAB1235)
- SKU:
- CAB1235
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-Syndecan-1/CD138 Antibody |
| 抗体コード: | CAB1235 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-240 of human Syndecan-1/CD138 (NP_002988.3). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | Mouse lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-240 of human Syndecan-1/CD138 (NP_002988.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VATN LPPE DQDG SGDD SDNF SGSG AGAL QDIT LSQQ TPST WKDT QLLT AIPT SPEP TGLE ATAA STST LPAG EGPK EGEA VVLP EVEP GLTA REQE ATPR PRET TQLP TTHQ ASTT TATT AQEP ATSH PHRD MQPG HHET STPA GPSQ ADLH TPHT EDGG PSAT ERAA EDGA SSQL PAAE GSGE QDFT FETS GENT AVVA VEPD RRNQ SPVD QGAT |
| 遺伝子ID: | 6382 |
| Uniprot: | P18827 |
| セルラーロケーション: | Membrane, Secreted, Single-pass type I membrane protein |
| 計算された分子量: | 32kDa |
| 観察された分子量: | 85kDa |
| 同義語: | SDC1, CD138, SDC, SYND1, syndecan |
| バックグラウンド: | The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. |
| UniProt Protein Function: | syndecan-1: Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Belongs to the syndecan proteoglycan family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Motility/polarity/chemotaxis; Extracellular matrix Chromosomal Location of Human Ortholog: 2p24.1 Cellular Component: cell surface; cytoplasm; focal adhesion; Golgi lumen; integral to plasma membrane; lysosomal lumen; plasma membrane Molecular Function:protein binding; protein C-terminus binding Biological Process: cell migration; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; glycosaminoglycan metabolic process; lipoprotein metabolic process; myoblast development; retinoid metabolic process; striated muscle cell development |
| NCBI Summary: | The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P18827 |
| NCBI GenInfo Identifier: | 229463011 |
| NCBI Gene ID: | 6382 |
| NCBI Accession: | P18827.3 |
| UniProt Secondary Accession: | P18827,Q53QV0, Q546D3, Q96HB7, D6W523, |
| UniProt Related Accession: | P18827,AAB21434,AAB23935 |
| Molecular Weight: | 32,462 Da |
| NCBI Full Name: | Syndecan-1 |
| NCBI Synonym Full Names: | syndecan 1 |
| NCBI Official Symbol: | SDC1 |
| NCBI Official Synonym Symbols: | SDC; CD138; SYND1; syndecan |
| NCBI Protein Information: | syndecan-1 |
| UniProt Protein Name: | Syndecan-1 |
| UniProt Synonym Protein Names: | CD_antigen: CD138 |
| Protein Family: | COMPASS component |
| UniProt Gene Name: | SDC1 |
| UniProt Entry Name: | SDC1_HUMAN |
 | Western blot analysis of extracts of Mouse lung cells, using Syndecan-1/CD138 antibody (CAB1235) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded human kidney cancer using Syndecan-1/CD138 antibody (CAB1235) at dilution of 1:200 (40x lens). |
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