| UniProt Protein Function: | STYXL1: a pseudophosphatase of the dual specificity phosphatase sub-family of the protein tyrosine phosphatases. Contains a Ser residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphoprotein phosphatase. The binding pocket may be however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases. Interacts with G3BP-1, an RNA-binding protein with endoribonuclease activity that is recruited to stress granules (SGs) during stress. SGs are involved in mRNA sorting in the storing of untranslated mRNAs. STYXL1 inhibits G3BP-induced stress granule formation. Five isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity Chromosomal Location of Human Ortholog: 7q11.23 |
| UniProt Code: | Q9Y6J8 |
| NCBI GenInfo Identifier: | 29840801 |
| NCBI Gene ID: | 51657 |
| NCBI Accession: | Q9Y6J8.1 |
| UniProt Secondary Accession: | Q9Y6J8,Q9UBP1, Q9UK06, Q9UK07, Q9UKG2, Q9UKG3, |
| UniProt Related Accession: | Q9Y6J8 |
| Molecular Weight: | 36kDa |
| NCBI Full Name: | Serine/threonine/tyrosine-interacting-like protein 1 |
| NCBI Synonym Full Names: | serine/threonine/tyrosine interacting like 1 |
| NCBI Official Symbol: | STYXL1 |
| NCBI Official Synonym Symbols: | DUSP24; MKSTYX; MK-STYX |
| NCBI Protein Information: | serine/threonine/tyrosine-interacting-like protein 1 |
| UniProt Protein Name: | Serine/threonine/tyrosine-interacting-like protein 1 |
| UniProt Synonym Protein Names: | Dual specificity phosphatase inhibitor MK-STYX; Dual specificity protein phosphatase 24; Map kinase phosphatase-like protein MK-STYX |
| Protein Family: | Serine/threonine/tyrosine-interacting-like protein |
| UniProt Gene Name: | STYXL1 |
