Anti-STRAP Antibody (CAB5964)
- SKU:
- CAB5964
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-STRAP Antibody |
抗体コード: | CAB5964 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF IP |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human STRAP (NP_009109.3). |
申し込み: | WB IF IP |
推奨希釈: | WB 1:1000 - 1:2000 IF 1:50 - 1:200 IP 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | Jurkat, HeLa, SW480, A-549, Mouse brain, Mouse lung, Mouse testis |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human STRAP (NP_009109.3). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MAMR QTPL TCSG HTRP VVDL AFSG ITPY GYFL ISAC KDGK PMLR QGDT GDWI GTFL GHKG AVWG ATLN KDAT KAAT AAAD FTAK VWDA VSGD ELMT LAHK HIVK TVDF TQDS NYLL TGGQ DKLL RIYD LNKP EAEP KEIS GHTS GIKK ALWC SEDK QILS ADDK TVRL WDHA TMTE VKSL NFNM SVSS MEYI PEGE ILVI TYGR SIAF HSAV SLDP IKSF EAPA TINS ASLH PEKE FLVA GGED FKLY KYDY NSGE ELES YKGH FGPI HCVR FSPD GELY ASGS EDGT LRLW QTVV GKTY GLWK CVLP EEDS GELA KPKI GFPE TTEE ELEE IASE NSDC IFPS APDV KA |
遺伝子ID: | 11171 |
Uniprot: | Q9Y3F4 |
セルラーロケーション: | Cytoplasm, Nucleus |
計算された分子量: | 38kDa/39kDa |
観察された分子量: | 39kDa |
同義語: | STRAP, MAWD, PT-WD, UNRIP |
バックグラウンド: |
UniProt Protein Function: | STRAP: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. STRAP may play a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Binds directly to GEMIN6 and GEMIN7. Associates with the complex in the cytoplasm but not in the nucleus. Also interacts with CSDE1/UNR and MAWBP. Interacts with PDPK1. Belongs to the WD repeat STRAP family. |
UniProt Protein Details: | Protein type:RNA splicing; Adaptor/scaffold Chromosomal Location of Human Ortholog: 12p12.3 Cellular Component: nucleoplasm; cytoplasm; plasma membrane; SMN complex; nucleus; cytosol Molecular Function:protein binding; receptor binding Biological Process: spliceosomal snRNP biogenesis; transforming growth factor beta receptor signaling pathway; maintenance of gastrointestinal epithelium; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of epithelial cell proliferation |
UniProt Code: | Q9Y3F4 |
NCBI GenInfo Identifier: | 12643951 |
NCBI Gene ID: | 11171 |
NCBI Accession: | Q9Y3F4.1 |
UniProt Secondary Accession: | Q9Y3F4,Q5TZT4, Q9NTK0, Q9UQC8, B2R5S5, B4DNJ6, |
UniProt Related Accession: | Q9Y3F4 |
Molecular Weight: | 350 |
NCBI Full Name: | Serine-threonine kinase receptor-associated protein |
NCBI Synonym Full Names: | serine/threonine kinase receptor associated protein |
NCBI Official Symbol: | STRAP |
NCBI Official Synonym Symbols: | MAWD; PT-WD; UNRIP |
NCBI Protein Information: | serine-threonine kinase receptor-associated protein; unr-interacting protein; WD-40 repeat protein PT-WD; MAP activator with WD repeats |
UniProt Protein Name: | Serine-threonine kinase receptor-associated protein |
UniProt Synonym Protein Names: | MAP activator with WD repeats; UNR-interacting protein; WD-40 repeat protein PT-WD |
Protein Family: | Serine-threonine kinase receptor-associated protein |
UniProt Gene Name: | STRAP |
UniProt Entry Name: | STRAP_HUMAN |
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