Anti-STRADB Antibody (CAB8651)
- SKU:
- CAB8651
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Frequently bought together:
Description
| 抗体名: | Anti-STRADB Antibody |
| 抗体コード: | CAB8651 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 209-418 of human STRADB (NP_061041.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:200 - 1:1000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | HT-29, Mouse liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 209-418 of human STRADB (NP_061041.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LVKH GQRH RAVY DFPQ FSTS VQPW LSPE LLRQ DLHG YNVK SDIY SVGI TACE LASG QVPF QDMH RTQM LLQK LKGP PYSP LDIS IFPQ SESR MKNS QSGV DSGI GESV LVSS GTHT VNSD RLHT PSSK TFSP AFFS LVQL CLQQ DPEK RPSA SSLL SHVF FKQM KEES QDSI LSLL PPAY NKPS ISLP PVLP WTEP ECDF PDEK DSYW EF |
| 遺伝子ID: | 55437 |
| Uniprot: | Q9C0K7 |
| セルラーロケーション: | Cytoplasm, Nucleus |
| 計算された分子量: | 31kDa/42kDa/47kDa |
| 観察された分子量: | 47kDa |
| 同義語: | STRADB, ALS2CR2, CALS-21, ILPIP, ILPIPA, PAPK, PRO1038 |
| バックグラウンド: | This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | STLK6: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Motility/polarity/chemotaxis; STE group; STE20 family; STLK subfamily Chromosomal Location of Human Ortholog: 2q33.1 Cellular Component: cytoplasm; cytosol; nucleus Molecular Function:protein binding; protein kinase activity Biological Process: activation of protein kinase activity; cell cycle arrest; protein amino acid phosphorylation; protein export from nucleus |
| NCBI Summary: | This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011] |
| UniProt Code: | Q9C0K7 |
| NCBI GenInfo Identifier: | 74762722 |
| NCBI Gene ID: | 55437 |
| NCBI Accession: | Q9C0K7.1 |
| UniProt Secondary Accession: | Q9C0K7,Q5BKY7, Q9P1L0, |
| UniProt Related Accession: | Q9C0K7 |
| Molecular Weight: | 31,219 Da |
| NCBI Full Name: | STE20-related kinase adapter protein beta |
| NCBI Synonym Full Names: | STE20-related kinase adaptor beta |
| NCBI Official Symbol: | STRADB |
| NCBI Official Synonym Symbols: | PAPK; ILPIP; ILPIPA; ALS2CR2; CALS-21; PRO1038 |
| NCBI Protein Information: | STE20-related kinase adapter protein beta |
| UniProt Protein Name: | STE20-related kinase adapter protein beta |
| UniProt Synonym Protein Names: | Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein; CALS-21; ILP-interacting protein; Pseudokinase ALS2CR2 |
| Protein Family: | STE20-related kinase adapter protein |
| UniProt Gene Name: | STRADB |
| UniProt Entry Name: | STRAB_HUMAN |
 | Western blot analysis of extracts of various cell lines, using STRADB antibody (CAB8651) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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