Anti-STK38 Antibody (CAB8191)
- SKU:
- CAB8191
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | STK38 Rabbit Polyclonal Antibody |
| 抗体コード: | CAB8191 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human STK38 (NP_009202.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | A-549, SW480, 293T, MCF7, Mouse liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human STK38 (NP_009202.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MAMT GSTP CSSM SNHT KERV TMTK VTLE NFYS NLIA QHEE REMR QKKL EKVM EEEG LKDE EKRL RRSA HARK ETEF LRLK RTRL GLED FESL KVIG RGAF GEVR LVQK KDTG HVYA MKIL RKAD MLEK EQVG HIRA ERDI LVEA DSLW VVKM FYSF QDKL NLYL IMEF LPGG DMMT LLMK KDTL TEEE TQFY IAET VLAI |
| 遺伝子ID: | 11329 |
| Uniprot: | Q15208 |
| セルラーロケーション: | Cytoplasm, Nucleus |
| 計算された分子量: | 54kDa |
| 観察された分子量: | 60kDa |
| 同義語: | STK38, NDR, NDR1 |
| バックグラウンド: | This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | NDR1: is an AGC kinase of the NDR family. An apparent upstream regulator of Myc activity in human B-cell lymphoma. Mediates apoptosis downstream of the tumor suppressor proteins RASSF1A and MST1. Reduced expression of NDR1 results in defective apoptotic responses and a predisposition to develop T cell lymphoma in mice. Activated by binding of S100B which releases autoinhibitory N-lobe interactions. Ubiquitously expressed with highest levels observed in peripheral blood leukocytes. |
| UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, AGC; EC 2.7.11.1; AGC group; NDR family Chromosomal Location of Human Ortholog: 6p21 Cellular Component: cytoplasm; nucleus Molecular Function:ATP binding; magnesium ion binding; mitogen-activated protein kinase kinase kinase binding; protein binding; protein serine/threonine kinase activity Biological Process: negative regulation of MAP kinase activity; peptidyl-serine phosphorylation; protein amino acid phosphorylation; protein modification process |
| NCBI Summary: | This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015] |
| UniProt Code: | Q15208 |
| NCBI GenInfo Identifier: | 56749457 |
| NCBI Gene ID: | 11329 |
| NCBI Accession: | Q15208.1 |
| UniProt Secondary Accession: | Q15208,Q503A1, |
| UniProt Related Accession: | Q15208 |
| Molecular Weight: | 54,190 Da |
| NCBI Full Name: | Serine/threonine-protein kinase 38 |
| NCBI Synonym Full Names: | serine/threonine kinase 38 |
| NCBI Official Symbol: | STK38 |
| NCBI Official Synonym Symbols: | NDR; NDR1 |
| NCBI Protein Information: | serine/threonine-protein kinase 38 |
| UniProt Protein Name: | Serine/threonine-protein kinase 38 |
| UniProt Synonym Protein Names: | NDR1 protein kinase; Nuclear Dbf2-related kinase 1 |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | STK38 |
| UniProt Entry Name: | STK38_HUMAN |
 | Western blot analysis of extracts of various cell lines, using STK38 antibody (CAB8191) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of U2OS cells using STK38 antibody (CAB8191) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of L929 cells using STK38 antibody (CAB8191) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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